刘密

发布者:金雪明发布时间:2022-07-05浏览次数:10431

姓名:刘密

职称职务:特聘教授

院系:药学院药剂系

电子邮箱:mi.liu@suda.edu.cn

办公地址:云轩楼1435

 

个人简历:2010年北京大学药学院硕士毕业,2014年苏黎世瑞士联邦理工学院 (ETH Zürich)药学院药剂系博士毕业,201411月份进入哈佛大学医学院免疫系从事博士后研究。201812月份加入苏州大学药学院药剂系任特聘教授,博士生导师。主要从事预防性和治疗性癌症疫苗、癌细胞特异性检测技术、mRNA疫苗、免疫多靶点检测技术等的研究。以通讯作者或第一作者在Nature Communications, Advanced Materials, Advanced Functional Materials, Analytical ChemistryiScience等国际一流杂志发表论文多篇,多篇论文以封面和亮点论文发表并引起关注,所做研究实用性较强,与药企有紧密合作,有多个项目成功实现转化。作为第一发明人已申请关于预防和治疗性癌症疫苗、癌细胞特异性检测技术、mRNA疫苗递送技术和免疫多靶点检测技术等国际发明专利和国内发明专利20多项,其中已经授权6项,部分国际发明专利已经进入美国、欧盟、日本、加拿大、韩国、澳大利亚和巴西。已有11项发明专利成功转让给生物医药企业,实现产学研良性互动。

 

研究方向:

1)预防性和治疗性癌症疫苗

2T细胞治疗

3mRNA疫苗递送技术

4)癌细胞特异性检测技术

5)免疫多靶点检测技术

6癌症免疫微环境分析

 

代表性论文

1Lu Diao,  Lin Ma,Junping Cheng,Yunzhi Pan,  Zuofu Peng,  Lianjun Zhang,  Minghao Xu,  Yupei Li,  Xuenong Zhang,  Honglv Jiang,  Guoqiang Xu,Fenghua Meng,  Zhiyuan Zhong,and Mi Liu*, Across-cancer specific immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis, iScience, 2022,25,105511 (1IF=6.107).

2fang Ji#, Minghao Xu#, Yunzhi Pan#, Lu Diao, Lin Ma, Li Qian, Junping Cheng*, Mi Liu*Lipid microparticles show similar efficacy with lipid nanoparticles in delivering mRNA and preventing cancerPharmaceutical Research, 2022, in press (2区,IF=4.580).

3Jianting Ma, Zuofu Peng, Lin Ma, Lu Diao, Xinyu Shao, Zhiming Zhao, Lele Liu, Liang Zhang, Chenrong Huang, and Mi Liu*A Multiple-Target Simultaneous Detection Method for Immunosorbent Assay and Immunospot AssayAnalytical Chemistry, 2022, 94, 8704−8714 (1区,IF=8.008).

4 Lin Ma, Lu Diao, Zuofu Peng, Yun Jia, Huimin Xie, Baisong Li, Jianting Ma, Meng Zhang, Lifang Cheng, Dawei Ding, Xuenong Zhang, Huabing Chen, Fengfeng Mo, Honglv Jiang, Guoqiang Xu, Fenghua Meng, Zhiyuan Zhong, Mi Liu*, Immunotherapy and prevention of cancer by nanovaccines loaded with whole-cell components of tumour tissues or cells, Advanced Materials, 2021,43, 2104849 (1区,IF =32.086).

5 Mi Liu, Jean-Christophe Leroux, Marc Andre Gauthier, Conformation–function relationships for the comb-shaped polymer pOEGMA, Progress in Polymer Science, 2015, 48, 111–121 (1区,IF =31.281).

6Mi Liu, Pål Johansen, Jean-Christophe Leroux, and Marc Andre Gauthier, Semi-permeable coatings fabricated from comb-polymers efficiently protect proteins in vivo, Nature Communications, 2014, 05, 5526 (1区,IF=17.694).

7Mi Liu, Pasquale Tirino, Milos Radivojevic, Daniel J. Phillips, Matthew I. Gibson, Jean-Christophe Leroux, Marc Andre Gauthier, Molecular sieving on the surface of a protein provides protection without loss of activity. Advanced Functional Materials, 2013, 23, 2007–2015 (1区,IF =19.924).

 

代表性荣誉

Mary K. Iacocca Genetics/Immunology Fellowship,         07.2017-07.2018, 哈佛大学医学院

Mary K. Iacocca Fellowship,                                             07.2015-07.2016, 哈佛大学医学院