张真庆

发布者:金雪明发布时间:2022-07-09浏览次数:5841

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姓名:张真庆

职务职称:特聘教授、博士生导师;药物分析系主任

电子邮箱:z_zhang@suda.edu.cn

办公地址:云轩楼1129办公室电话: 0512-65882593

课题组链接:http://pharm.suda.edu.cn/8f/fc/c11661a364540/page.htm

个人简介


张真庆教授,现任CDE糖类药品评审专家,担任中国药学会药分委员会和生物制药协会糖类药物专家委员等多项职务。主要从事糖类药物研究逾20年,在糖类药物的分析方法学、质量控制、结构解析、活性研究等领域取得丰硕成果。张真庆教授实验室拥有完备的药学研究平台;创立了二维液相、离子色谱质谱联用、毛细管质谱联用等多个糖类药物分析特色研究系统;协助逾十家企业完成了多个品种肝素类药物的一致性评价;领衔抗老年痴呆国家一类新药GV-971的结构、工艺、质量、体内药动学等研究,助力了GV-971上市。张真庆教授在多糖相关药物的质量控制、体内代谢等研究领域中作出重要贡献,先后发表SCI论文百余篇,包括Nature BiotechJACSPNASAnal. Chem等领域顶级期刊,主持国多项自然面上项目。张真庆教授获得多项荣誉,包括张天民糖类药物“杰出青年奖”、江苏省双创人才、江苏省六大人才高峰、江苏省双创团队核心成员、苏州市优秀人才贡献奖等,同时担任中国药学会药物分析专业委员会委员、中国医药生物技术协会药物分析技术分会常务委员、生物制药协会糖类药物专家委员以及《药物分析杂志》编辑委员会委员等职务。

教育情况

1996-2000中国海洋大学,药学,本科

2000-2003中国海洋大学,药物化学,硕士

2003-2006中国海洋大学,糖化学,博士


工作经历

2006-2009Rensselaer Polytechnic Institute糖组学、糖类药物研究,博士后

2009-2012Baxter Healthcare Corporation糖组学、糖类药物研究,Research Scientist

2012-至今,苏州大学药学院,糖组学、糖类药物研究,特聘教授

主要荣誉

2007Awarded to the “top 50 cited” Carbohydrate Research paper by Dr. Zhang, Volume 339, Issue 8 (2004), Pages 1475-1481. Elsevier, Oxford, UK.

2009Nominated as a candidate to The New York Academy of Sciences Blavatnik Awards for Young Scientists by Rensselaer Polytechnic Institute (RPI), NY, USA.

2012Baxter Corporate Technology Award

2012江苏省特聘教授

2013江苏省“双创”引进人才

2014江苏省“双创团队”核心成员

2017江苏省“六大高峰人才”

2021张天民糖类药物“杰出青年奖”

研究方向

1.糖药物结构、制备工艺、质量控制

2. 糖药物-免疫学构效关系研究

3. 糖药物-神经退行性疾病构效关系研究

4. 肝素类药物糖组学研究

5. 抗体药物糖基化研究

6. 多糖铁剂、多糖纳米载药系统研究

近五年主要发表文章(*indicdates corresponding authors; 1indicates contributed equally)

1. N. Yan, F. Song, Y. Ouyang, D. Li, H. Tian, L. Yi*, R. J. Linhardt, Z. Zhang*; Glycan mapping of low-molecular-weight heparin using mass spectral correction based on chromatography fitting withGlycomappingsoftware,Analytical Chemistry, 2022, 94: 1300013009.1,  IF:8.0

2. J. Lu, Q. Pan, J. Zhou, Y. Weng, K. Chen, L. Shi, G. Zhu, C. Chen, L. Li*, M. Geng, Z. Zhang*; Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China,Journal of Pharmaceutical Analysis,2022, 12: 145-155.1,  IF:14.0

3. N. U. Ain , S. Wu , X. Li, D. Li*, Z. Zhang*; Isolation, characterization, pharmacology and biopolymer applications of licorice polysaccharides: review, Materials, 2022, 15: 3654-3676. 1,  IF:3.6

4. L. Chen, W. Zhu, N. Yan, Y. Guo, L. Yi, Y. Ouyang*, Z. Zhang*; Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS, Journal of Pharmaceutical and Biomedical Analysis, 2022, 212:114616-114323. 3,  IF:3.6

5. F. Wu, N. Yan, Y. Guo, X. Yu, L. Yi, Y. Ouyang, X. Wang*, Z. Zhang*; Pattern of Specific Oxidation of Konjac Glucomannan with TEMPO/NaBr/ NaClO system, Carbohydrate Research, 2022, 515: 108558-108566. 3,  IF:4.0

6. W. Zhu, L. Chen, N. Yan, L. Yi, Y. Sun, Y Ouyang, D. Liu, Z. Zhang*; Sequencing analysis of heparin reducing terminals with orthogonal chromatographic approaches, Journal of Chromatography A, 2022, 1677: 463318-463326. 2,  IF:4.6

7. L. Chen; Y. Ouyang; N. Yan; Y. Guo; L. Yi; Y. Sun; D. Liu; Z. Zhang*; Comprehensive analysis of heparinase derived heparin-products using two-dimensional liquid chromatography coupled with mass spectrometry, Journal of Chromatography A, 2021, 1643: 462042-462049. 2,  IF:4.6

8. B. Xie1, L. Yi1, Y. Zhu, X. Chang, J. Hao, L. Pang, Y. Ouyang, S. Yuan, Z. Zhang* Structural elucidation of a novel branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system, Carbohydrate Polymers,2021, 251: 117080-117091. 1,  IF:10.7

9. P. Qiu, F. Wu, L. Yi, L. Chen,Y. Jin, X Ding, Y. Ouyang, Y. Yao, Y. Jiang, Z. Zhang*, Structure characterization of a heavily fucosylated chondroitin sulfate from sea cucumber (H. leucospilota) with bottom-up strategies, Carbohydrate Polymers, 2020, 240, 116337. 1,  IF:10.7

10. J. Hao, F. Wu, R. Tang, Y. Sun, D. Liu*, Z. Zhang* Preparation of 1,4-linked α-D-glucuronans from starch with 4-acetamide-TEMPO/NaClO2/NaClO system,  International Journal of Biological Macromolecules,2020, 151:740-746. 2,  IF:8.0

11. D. Bi, X. Li , T. Li, X. Li, Z. Lin, L. Yao, H. Li, H. Xu, Z. Hu, Z. Zhang*, Q. Liu* and X Xu* Characterization and Neuroprotection Potential of Seleno-Polymannuronate,Frontiers in Pharmacology, 2020,11: 21, 2区,IF:6.0

12. Y. Meng, L. Yi, L. Chen, J. Hao, D. Li, J. Xue*, N. Xu, Z.Zhang*. Purification, structure characterization and antioxidant activity of polysaccharides from Saposhnikovia divaricate, Chinese Journal of Natural Medicines.2019, 17(10): 0792-0800, 4IF:  3.9

13. Y. Ouyang, M. Zhu, X.Wang, L. Yi, Y. Yao, J. Fareed, R. J Linhardt*, Z. Zhang,*Systematic analysis of enoxaparins from different sources with online one and two-dimensional chromatography, Analyst.2019, 144, 3746-3755.2区,IF:5.2

14. Y. Ouyang, Y. Yu, F. Zhang, J. Chen, X. Han, K. Xia, Y.Yao, Z. Zhang,* R.J. Linhardt*, Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications, Journal of Medicinal Chemistry, 2019, 62, 1067-1073.2区,IF:8.0.

15. Y. Ouyang, X. Han, Q. Xia, J. Chen, S. Velagapudi, K. Xia,Z. Zhang* and R.J Linhardt* Negative-ion Mode Capillary Isoelectric Focusing-Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides, Analytical Chemistry, 2019, 91, 846-853. 1区,IF:8.0

16. R. Cheng, X. Tang, A. Long, J. Mwangi, R. Lai, R. Sun, C. Long, Z. Zhang*. Purification and characterization of a novel anti-coagulant from the leech Hirudinaria manillensis.Zoological Research. 2019, 40(3): 205-210. 1区,IF:7.0

17. F. WuK. Dong, M. Zhu, Q. Zhang, B. Xie, D. Li, H.Gan, Z. Zhang* Development of a method to analyze the complexes of enoxaparin and plateletfactor 4 with size-exclusion chromatography, Jounral of Pharmaceutical and Biomedical Analysis, 2019, 164, 668-671. 3,  IF3.6

18. Y. Ouyang, X. Han, Y. Yu, J. Chen, L. Fu, F. Zhang, R. Linhardt, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta, Z. Zhang,* K. Xia*. Chemometric analysis of porcine, bovine and ovine heparins, Jounral of Pharmaceutical and Biomedical Analysis, 2019, 164, 345-352. 3,  IF3.6

19. L. Yi, Q. Zhang, Y. Meng, J. Hao, B. Xie, H. Gan, D. Li, K. Dong, Z. Zhang*  Qualitative and quantitative analysis of 2, 5-anhydro-D-mannitol in low molecular weight heparins with high performance anion exchange chromatography hyphenated quadrupole time of flight mass spectrometry, Journal of Chromatography A. 2018, 1569:160-167. 2区,IF:4.6

20. Z. Liu, Y. Xiong, L. Yi, R. Dai, Y. Wang, M. Sun, X. Xiao, Z. Zhang*, S. Yuan*, Endo-β-1,3-glucanase digestion combined with the HPAEC-PAD-MS/MS analysis reveals the structural differences between two laminarins with different bioactivities, Carbohydrate Polymers, 2018, 194, 339-349. 1,  IF:10.7

21. R. Tang1, J. Hao1, R.Zong, F. Wu, Y. Zeng, Z. Zhang*, Oxidation pattern of curdlan with TEMPO-mediated system, Carbohydrate Polymers, 2018, 186, 9-16. 1,  IF:10.7

22. Y. Ouyang, Y. Zeng, L. Yi, H. Tang, D. Li, R. Linhardt, Z. Zhang* Qualitative and quantitative analysis of heparin and low molecular weight heparins using size exclusion chromatography with multiple angle laser scattering/refractive index and inductively coupled plasma/mass spectrometry detectors, Journal of Chromatography A. 2017, 1522(3): 56-61, 2区,IF:4.6

23. L. Xu, Z. Zhang*, X. Sun, J. Wang, W. Xu, L. Shi, J. Lu, J. Tang, J. Liu, X. Su.Glycosylation status of bone sialoprotein and its role in mineralization,Experimental cell research, 2017, 17:30514-1. 2区,IF:4.1

24. Y. Rong, N Xu, B Xie, J Hao, L Yi, R Cheng, D Li, R. J. Linhardt, Z. Zhang,* Sequencing analysis of β-glucan from highland barley with high performance anion exchange chromatography coupled to quadrupole time – of – flight mass spectrometry, Food Hydrocolloids,2017, 73, 235-242. 1区,IF:11.5

25. X. Sun, L. Tao, L. Yi, Y. Ouyang, N. Xu, D. Li, R. Linhardt, Z. Zhang* N-glycans released from glycoproteins using a commercial kit andcomprehensively analyzed with a hypothetical database, Journal of Pharmaceutical Analysis, 2017, 7(2): 87-94.  1,  IF14.0

26. L. Tao, F. Song, N. Xu, D. Li, R.J. Linhardt, Z. Zhang* New Insights into the Action of Bacterial Chondroitinase AC I and Hyaluronidase on Hyaluronic Acid, Carbohydrate Polymers, 2017, 158: 85-92. 1,  IF:10.7

27. J. Hao, S. Xu, N. Xu, D. Li, R.J Linhardt, Z. Zhang*  Impact of Degree of Oxidation on the Physicochemical Properties of Microcrystalline Cellulose Carbohydrate Polymers, 2017, 155, 483-490.1,  IF:10.7

授权专利(第一发明人)

1. 一种针筒式滤膜过滤器收纳盒,授权日期:2021.11.23,专利号:CN202120450809.X

2. 一种分析天平称量配件组合收纳装置,授权日期:2021.11.23,专利号:CN202120397765.9

3. 一种风琴式色谱柱收纳包,授权日期:2021.05.14,专利号:CN202021705367.0

4. 一种离子色谱-质谱联用在线检测保护装置,授权日期:2021.05.14,专利号:CN202021478056.5

5. 一种北沙参多糖及其制备方法和应用,授权日期:2021.11.02,专利号:CN202010704732.4

6. 氧化型1,4-β-D-葡萄糖醛酸寡糖在制备治疗阿尔茨海默病的药物中的应用,授权日期:2021.03.02,专利号:CN201811136880.X

7. 一种分离的防风多糖及其用途,授权日期:2022.01.18,专利号:CN201810114242.1

8. 一种分离的防风多糖及其用途,授权日期:2022.03.04,专利号:CN201810114240.2

9. 一种β-1,3-葡萄糖醛酸寡糖、及其制备方法和用途;授权日期:2022.06.21,专利号:CN202010187802.3

10. 不饱和透明质酸奇数寡糖及其制备方法,授权日期:2019.05.03,专利号:CN201611020047.X

11. 一种氧化型α‑1,4‑寡聚葡萄糖醛酸及其制备方法和用途,授权日期:2021.03.16,专利号:CN201680029752.8

12. 一种氧化型β-1,4-寡聚葡萄糖醛酸及其制备方法和用途,授权日期:2018.06.19,专利号:CN201510267009.3

13. 一种氧化型α-1,4-寡聚葡萄糖醛酸及其制备方法和用途,授权日期:2018.08.24,专利号:CN201510267211.6

申请专利(第一发明人,审中)

1. 一种速率反应装置、方法及其在发色底物法上的应用,申请日期:2022.04.28,申请号:CN202210460775.1

2. 一种用于低分子量肝素质量分析的二维液相-质谱联用方法,申请日期:2022.04.08,申请号:CN202210365757.5

3. 一种部分抗凝肝素衍生物及其制备方法和应用,申请日期:2022.02.25,申请号:CN202210176221.9

4. 一种色谱质谱分析用数据处理方法,申请日期:2022.01.06,申请号:CN202210008618.7

5. 一种鼠尾静脉注射、采血装置,申请日期:202220927450.5,申请号:2022.04.21

6. 一种简便型多功能实验玻璃容器清洁手枪,申请日期:2022.08.02,申请号:202222009745.7

7. β-1,4型葡萄糖醛酸/甘露糖醛酸直链杂合寡糖及其制备方法和应用,2021.08.31CN202111010709.6

8. 一种β-14型葡萄糖醛酸/甘露糖醛酸直链杂合寡糖及其制备工艺,申请日期:2021.03.17,申请号:CN202110284424.5

9. 一种串联凝集素亲和柱纯化海参多糖装置及其使用方法,申请日期:2020.11.03,申请号:CN202010717625.5

10. 一种分离的白茅根多糖及其用途,申请日期:2018.02.05申请号:CN201810112124.7

11. 一种分离的防风多糖的制备方法及其药物用途,申请日期:2018.02.05申请号:CN201810114242.1

12. 一种测定肝素类药物重均分子量和含量的方法,申请日期:2017.09.06,申请号:CN2017107953651

13. 一种测定酸性糖重均分子量和含量的方法,申请日期:2017.09.06,申请号:CN201710795513X

14. 一种青稞β葡聚糖的制备工艺及其结构序列,申请日期:2017.0526,申请号:CN201710382822.4

软件著作

1. 基于色谱拟合质谱归属校正的复杂体系分析软件V1.0Glycomapping v1.0),著作权人:苏州大学,登记号:2022SR0739945