滕昕辰

发布者:滕昕辰发布时间:2018-12-03浏览次数:5338



滕昕辰

特聘副教授

苏州大学药学院

电子邮箱: xcteng@suda.edu.cn


工作经历

10/2013至今

苏州大学,医学部药学院,特聘副教授


教育经历

05/2010 – 09/2013

美国约翰霍普金斯大学,公共卫生学院,分子微生物及免疫学系,博士后


09/2004 – 05/2010

美国约翰霍普金斯大学,医学院,生物化学、细胞与分子生物学系,博士


09/2001 – 06/2004   

复旦大学,化学系,硕士


09/1998 – 06/2001

复旦大学,化学系,学士


奖励

08/2020   第三届江苏省本科高校青年教师教学竞赛二等

12/2015苏州大学第十四届青年教师课堂教学竞赛一等奖

09/2014   苏州市紧缺人才

09/2014   江苏省双创博士

06/2011美国Phi Beta Kappa学会会员


研究项目

感应特定氨基酸信号的新型TORC1调控因子的筛选及机制研究

中国国家自然基金面上项目31970550, 01/2020-12/2023


KCTD蛋白对TORC1信号通路的调控机制及对肿瘤生成的影响

中国国家自然基金青年项目31401197, 01/2015-12/2017


KCTD11TORC1信号通路的调控机制研究

江苏省自然基金青年项目BK20140318, 07/2014-06/2017


研究成果

科研论文:

Yang X, Wang G, Cao T, Zhang L, Ma Y, Jiang S, Teng X, Sun X* (2019) Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia, J Biol Chem. 294, 12921-12932.


Metz KA, Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM (2018) KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect, Ann Neurol. 84, 766-780


Chen X, Wang G, Zhang Y, Dayhoff-Brannigan M, Diny NL, Zhao M, He G, Sing CN, Metz KA, Stolp ZD, Aouacheria A, Cheng WC, Hardwick JM*, Teng X* (2018) Whi2 is a conserved negative regulator of TORC1 in response to low amino acids, PLoS Genetics. 14, e1007592


Teng X, Dayhoff-Brannigan M, Cheng W-C, Gilbert CE, Wheelan SJ, Dunham MJ, Boeke JD, Pineda FJ and Hardwick JM (2013) Genome-wide consequences of deleting any single gene, Mol Cell. 52, 485-494.


Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM (2011) Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential, J Cell Biol.195, 263-76


Teng X, Cheng W-C, Qi B, Yu T-X, Ramachandran K, Boersma MD, Hattier T, Lehmann PV, Pineda FJ and Hardwick JM (2011) Gene-dependent cell death in yeast, Cell Death Dis.2, e188


Cheng W-C, Teng X, Park HK, Tucker CM, Dunham MJ and Hardwick JM (2008) Fis1-deficiency selects for compensatory mutations responsible for cell death and growth control defects, Cell Death Differ. 15, 1838-1846


综述

Teng X, Aouacheria A, Lionnard L, Metz KA, Soane L, Kamiya A, Hardwick JM* (2019) KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders, CNS Neurosci Ther. 25, 887-902.


Teng X* and Hardwick JM* (2018) Whi2: a new player in amino acid sensing, Curr Genet. 65, 701-709.


Teng X, Yau E, Sing C, Hardwick JM (2018) Whi2 signals low amino acid availability to halt yeast growth and cell death, FEMS Yeast Res. 18, foy095


Teng X* and Hardwick JM* (2015) Cell death in genome evolution, Semin Cell Dev Biol. 39, 3-11


Teng X* and Hardwick JM* (2014) Genome evolution in yeast reveals connections between rare mutations in human cancers, Microb Cell. 1, 206-209


Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM and White K (2010) Mitochondrial involvement in cell death of non-mammalian eukaryotes, Biochim Biophys Acta. 1813, 597-607  


Teng X and Hardwick JM (2010) The apoptosome at high resolution, Cell. 141, 404-406


书籍章节

Teng X and Hardwick JM (2013) The extrinsic cell death pathway, Molecular Oncology. 353-366


Teng X and Hardwick JM (2013) Quantification of genetically controlled cell death in budding yeast, Methods Mol Biol.1004, 161-70


Teng X and Hardwick JM (2009) Reliable method for detection of programmed cell death in yeast, Methods Mol Biol. 552, 335-342


学生项目

莙政学者项目(2014~2015

校级大学生课外科研项目(20142015201620192020

省级大学生创新创业项目(2014~2016 一般项目,2020~2022 重点项目)