孙雄华

发布者：金雪明发布时间：2018-12-03浏览次数：4421

 



研究内容

肺纤维化生物活性成分的发现及其作用机制研究


学习经历

1996/09-2000/06，山东医科大学，药学院，学士

2003/09-2006/06，中国药科大学，生命科学与技术学院，硕士

2007/09-2013/06，苏州大学，医学院，博士


工作经历

2000/08－至今，苏州大学，苏州医学院药学院，助教，讲师，副教授


发表论文

  1. Xionghua Sun#,Xuelei Wan#,Li Chen,Xihua Chen, Jian Zhang,Xiaogang Jiang. Mitomycin induced the senescence of alveolar epithelial cells by targeting peroxiredoxin I.Biochemical Pharmacology,2025,236, 116890.

  2. Xionghua Sun#, Mei Zhu#, Wei Xia#, Xihan Xu, Jian Zhang, Xiaogang Jiang. Total sesquiterpenoids from Eupatorium lindleyanum DC. attenuate bleomycin-induced lung fibrosis by suppressing myofibroblast transition.Fitoterapia, 2023, 169, 105567

  3. Xionghua Sun, Xiaogang Jiang. Collagen targeting liposomes, a promising strategy for idiopathic pulmonary fibrosis.Journal of Controlled Release, 2023, 361, 896-897.

  4. Xionghua Sun, Xiaogang Jiang. Comment on “Reactive oxygen species-responsive polypeptide drug delivery system targeted activated hepatic stellate cells to ameliorate liver fibrosis”.ACS nano, 2023, 17, 4094-4095.

  5. Mei Zhu, Jian Zhang,Xionghua Sun*, Xihua Chen, Xiaogang Jiang*. Eupafolin suppresses TGF-β1-induced human lung fibroblasts differentiation by downregulating β-catenin/plasminogen activator inhibitor-1 signaling.Pharmacological Research-Modern Chinese Medicine, 2022, 2, 100056.

  6. Xiafang Xu#,Xionghua Sun#, Xuelei Wan, Xihua Chen, Xiaogang Jiang. Mitomycin induces alveolar epithelial cell senescence by down-regulating GSK3β signaling.Toxicology Letters, 2021, 352, 61-69.

  7. Xionghua Sun, Mei Zhu, Xihua Chen, Xiaogang Jiang.MYH9 inhibition suppresses TGF-β1-stimulated lung fibroblast-to-myofibroblast differentiation.

Front. Pharmacol., 2021, 11, 573524.

  1. Xionghua Sun#, Xinjian Cui#, Xihua Chen, Xiaogang Jiang.Baicalein alleviated TGF β1-induced type I collagen production in lung fibroblasts via downregula-

tion of connective tissue growth factor. Biomed. Pharmacother., 2020,131, 110744.

  1. Fanqing Lu#,Xionghua Sun#, Xiafang Xu, Xiaogang Jiang.SILAC-based proteomic profiling of the suppression of TGF-β1-induced lung fibroblast-to-myofibroblast differentiation by trehalose. Toxicol. Appl. Pharmacol., 2020, 391, 114916.

  2. Xinjian Cui#,Xionghua Sun#, Fanqing Lu, Xiaogang Jiang. Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21. Toxicol. Appl. Pharmacol., 2018, 358, 35-42.

  3. Xiang Zhou#,Xionghua Sun#, Xiaogang Jiang. Comparative proteome profiling of bleomycin-induced lung toxicity in rats by 2D-nano-LC-MS/MS and spectral counting. Biomed. Chromatogr., 2017, 31，e3857.

  4. Xionghua Sun, Xiaogang Jiang.Automated platform of μLC-MS/MS using SAX trap column for highly efficient phosphopeptide analysis. Anal. Bioanal. Chem., 2017, 409, 2489-2493.

  5. Xionghua Sun, Xiaogang Jiang.Combination of FASP and fully automated 2D-LC-MS/MS allows in-depth proteomic characterization of mouse zymogen granules. Biomed. Chromatogr., 2013, 27, 407-408.

  6. Xionghua Sun, Zhaoyue Wang，Haiyan Yang，Lijuan Cao，Jian Su，Ziqiang Yu，Xia Bai，Changgeng Ruan. Clinical, pathological, and genetic analysis of ten patients with MYH9-related disease，Acta Haematol.,2013,129,106~113.