曹青日

发布者:金雪明发布时间:2022-07-08浏览次数:5398

姓  名:曹青日

职称职务:教授、博导

电子邮箱:qrcao@suda.edu.cn

办公地址:云轩楼1327


一、学习工作经历

1、学历背景:

1992.91996.6延边大学药学院,药学专业,学士

1998.92000.6韩国江原国立大学药学院,药剂学专业,硕士

2000.92004.2 韩国江原国立大学药学院,药剂学专业,博士

2、国外学习研究经历:

2004.22004.7韩国江原国立大学药学院,博士后

2004.82007.4 韩国希杰(CJ)株式会社药物研究所,高级研究员

2007.62008.8 韩国大熊制药药物研究所,高级研究员

2008.92009.2 韩国EuraPharm研究所,高级研究员

3、工作经历:

1996.91998.6延边大学药学院药剂教研室,助教

2009.32021.8 苏州大学医学部药学院,副教授、硕导

2021.9-至苏州大学医学部药学院,教授、博导

 

二、研究方向

1、口服缓控释制剂、长效微球、脂质体等新剂型开发与产业化研究

2肿瘤微环境响应性碳纳米载体(化疗、化疗和基因、化疗和免疫)的研究

3功能化纳米载体的胃肠道吸收、肿瘤细胞外基质穿透及循环肿瘤细胞靶向机制的研究

 

三、主要研究成果

  在教学方面,参与《药剂学》、《生物药剂学与药代动力学》、《现代药物制剂与新药研发》等本科、研究生课程的教学工作。在科研方面,主持或参与十项国家及省部级课题、二十余项企业技术攻关项目,积累了丰富的新药研发和产业化经验。在Journal of Controlled Release、ACS Applied Materials & Interfaces、Theranostics、Molecular Pharmaceutics、International Journal of Pharmaceutics等国内外期刊上发表学术论文50余篇,已获得授权发明专利15项。曾获2017年度中国医药城第六批“113人才计划”高层次创新人才项目及2018年江苏省“双创计划”科技副总项目。


1、发表论文(*表示为通讯作者)

1. Huang HY, Chen LQ, Sun W, Du HH, Dong SL, Cao DY, Ahmed AMQ, Cui JH, Zhang Y, Cao QR*, Collagenase IV and clusterin-modified polycaprolactone-polyethylene glycol nanoparticles for penetrating dense tumor tissues. Theranostics, 2021, 11(2): 906-924.

2. Meghani NM, Amin H, Park CH, Cui JH, Cao QR, Choi KH, Lee BJ, Combinatory interpretation of protein corona and shear stress for active cancer targeting of bioorthogonally clickable gelatin-oleic nanoparticles. Mat Sci Eng C, 2020, 111: 110760 (1-12).

3. Park C, Meghani N, Loebenberg R, Cui JH, Cao QR, Lee BJ. Fatty acid chain length impacts nanonizing capacity of albumin-fatty acid nanomicelles: Enhanced physicochemical property and cellular delivery of poorly water-soluble drug.Eur J Pharm Biopharm2020, 152: 257-269.

4. Xia YN, Li XH, Xu JH, Huang HY, Chen LQ, Ahmed AMQ, Du HH, Cao QR*, Optimization and characterization of novel sustained release micro-pellet-based dry suspensions that load dexibuprofen, J Drug Deliv Sci Tec, 2020,55: 101420 (1-7).

5. Chen LQ, Ahmed AMQ, Cao DY, Du HH, Cui JH, Lee BJ, Cao QR*, Novel triptorelin acetate-loaded microspheres prepared by a liquid/oil/oil method with high encapsulation efficiency and low initial burst release, J Drug Deliv Sci Tec, 2019, 54: 101390 (1-8).

6. Cao Y, Huang HY, Chen LQ, Cui JH, Zhang LSW, Lee BJ, Cao QR*. Enhanced lysosomal escape of pH-responsive polyethylenimine-betaine functionalized carbon nanotube for the codelivery of survivin small interfering RNA and doxorubicin. ACS Appl Mat Int, 2019, 11: 9763-9776.

7. Zhang XX, Huang HY, Chen LQ, Jin HH, Lee BJ, Cui JH, Cao QR*. Physicochemical characterization and cytotoxicity of chitosan-modified single walled carbon nanotubes as drug carriers. J Pharm Invest, 2019, 49(1): 57-65.

8. Li B, Zhang XX, Huang HY, Chen LQ, Cui JH, Liu YL, Jin HH, Lee BJ, Cao QR*. Effective deactivation of A549 tumor cells in vitro and in vivo by RGD-decorated chitosan-functionalized single-walled carbon nanotubes loading docetaxel. Int J Pharm, 2018, 5431-2:8-20.

9. Liu JY, Zhang XX, Huang HY, Lee BJ, Cui JH, Cao QR*. Esomeprazole magnesium enteric-coated pellet-based tablets with high acid tolerance and good compressibility. J Pharm Invest, 2018, 48: 341-350.

10. Shi LL, Lu J, Cao Y, Liu JY, Zhang XX, Zhang HJ, Cui JH*, Cao QR*. Gastrointestinal stability, physicochemical characterization and oral bioavailability of chitosan or its derivatives-modified solid lipid nanoparticles loading docetaxel. Drug Dev Ind Pharm, 2017,43(5): 839-846.

11. Shi LL, Xie HJ, Lu J, Cao Y, Liu JY, Zhang XX, Zhang HJ, Cui JH*, Cao QR*. Positively charged surface-modified solid lipid nanoparticles promote the intestinal transport of docetaxel through multifunctional mechanisms in rats. Mol Pharm, 2016,13(8): 2667-2676.

12. Cao Y, Shi LL, Cao QR*, Yang MS, Cui JH. In vitro characterization and oral bioavailability of organic solvent free solid dispersions containing telmisartan. Iran J Pharm Res, 2016, 15(2): 385-394.

13. Xu WJ, Xie HJ, Cao QR*, Shi LL, Cao Y, Zhu XY, Cui JH. Enhanced dissolution and oral bioavailability of valsartan solid dispersions prepared by a freeze-drying technique using hydrophilic polymers. Drug Deliv, 2016, 23(1):41-48.

14. Shi LL, Cao Y, Zhu XY, Cui JH, Cao QR*. Optimization of preparing process for zanamivir-loaded solid lipid nanoparticles and prediction of their cellular transport in Caco-2 cell model.Int J Pharm, 2015, 478(1-2): 60-69.

15. Xu LL, Xu WJ, Shi LL, Cao QR*, Cao Y, Zhu XY, Cui JH. Formulation and in vitro characterization of novel sildenafil citrate-loaded polyvinyl alcohol-polyethylene glycol graft copolymer-based orally dissolving films. Int J Pharm,2014, 473(1-2): 398-406.

16. Xu WJ, Liu Y, Shi LL, Cui JH, Cao QR*.In vitro dissolution and physicochemical characterizations of novel PVP-based solid dispersions containing valsartan prepared by a freeze-drying method. Pak J Pharm Sci, 2014, 27(6): 1799-1804.

17. Shi LL, Xu WJ, Cao QR*, Yang MS, Cui JH*. Preparation, characterization and in vitro evaluation of polyvinyl alcohol/sodium alginate based orodispersible film containing sildenafil citrate. Pharmazie, 2014, 69(5): 327-334.

18. Cao QR*, Piao YN, Choi JS, Liu Y, Yang MS, Cui JH*. Design, in vitro release characterization and pharmacokinetics of novel controlled release pellets containing levodropropizine. Pharm Dev Tech, 2014, 19(3): 296-303.

19. Cao QR*, Choi JS, Liu Y, Xu WJ, Yang MS, Lee BJ, CuiJH*. A formulation approach for development of HPMC-based sustained release tablets for tolterodine tartrate with a low release variation. Drug Dev Ind Pharm, 2013, 39(11):1720-1730.

 

2、授权专利

1曹青日,杜欢欢,夏亚男. 一种醋酸曲安奈德缓释微球及其制备方法,申请号:201910625578.9,申请日:2019-07-11

2曹青日,陈利清,阿特夫 穆罕默德 卡塞姆 艾哈迈德(Atef Mohammed Qasem Ahmed. 一种格拉司琼缓释微球的制备方法,申请号:201910103919.6,申请日:2019-02-01

3曹青日,魏腾. 恩替卡韦口腔速溶膜剂及其制备方法,申请号:201711027198.2,申请日:2017-10-26

4曹青日,刘疆燕,崔京浩. 靶向循环肿瘤细胞的长循环纳米粒及其制备和应用,申请号:201710356559.1,申请日:2017-05-19

5曹青日,刘疆燕,曹悦,崔京浩. 一种埃索美拉唑镁肠溶微丸制剂及其制备方法,申请号:CN201510071595.4,申请日:2015-02-11

6曹青日,徐卫娟,崔京浩. 一种pH敏感的碳纳米管靶向递药体系的制备方法,申请号:CN201410416979.0,申请日:2014-08-22

7曹青日,施丽丽,崔京浩. 西地那非口腔速溶膜剂及其制备方法,专利申请号:CN201410226345.9,申请日:2014-05-24

8曹青日,施丽丽,徐卫娟,崔京浩. 一种口腔速溶膜剂及其制备方法,专利申请号:CN201210363306.4,申请日:2012-09-29

9曹青日,刘妍,崔京浩. 一种富马酸喹硫平的缓释片剂,专利申请号:CN201210123709.1,申请日:2012-04-25

10曹青日,刘妍,崔京浩. 一种富马酸奎硫平缓释片及其制备方法,申请号:CN201110314104.6,申请日:2011-10-17

11曹青日,崔京浩.扎那米韦固体脂质纳米粒的口服制剂及其制备方法.申请号:CN201010590798.1,申请日:2010-12-16

 

3、科研项目

1阿霉素长循环脂质体的技术开发(P113203219 2019.11-2022.10,主持)

2注射用纳曲酮长效微球制剂的技术开发(P113200718, 2018.1-2020.12,主持)

3注射用醋酸曲普瑞林缓释微球的技术开发(201701-2021.12,主持)

4盐酸舍曲林口腔崩解片(2550mg的研究开发(P1132019162016.10-2020.9,主持

5吡嘧司特钾颗粒剂技术开发(P1132017152015.11-2018.10,主持)

6埃索美拉唑肠溶胶囊的研究开发(P1132012152015.5-2018.4,主持)

7盐酸美金刚缓释口服液的研究开发(P1132011142014.11-2017.11,主持)

8EGFR受体介导的肺肿瘤靶向siRNA类脂质载体的构建及转运调控机制研究(国家自然科学基金面上项目,813733332014.1-2017.12,主要参与)

9具受体介导的温敏性纳米载体对siRNA体内外传递及药效的影响和机制研究(国家自然科学基金面上项目,811730052012.01-2015.12,主要参与)

10有调控细胞紧密连接与M细胞特异性转运双功能纳米粒的口服吸收机制研究(苏州市应用基础医疗卫生,SYS201204N313207912),2012.9-2015.6,主持)

11、血管紧张素II受体-缬沙坦胃滞留型生物黏附性微丸的制备及其生物利用度评价研究(教育部留学回国人员科研启动基金项目,K5132006112011.01-2013.12,主持)