蒋小岗

发布者:金雪明发布时间:2018-11-04浏览次数:4913

 

  

电子邮箱:

jiangxiaogang@suda.edu.cn

研究方向:

   肺纤维化药理与毒理

研究内容:

1、肺成纤维细胞分化的药物干预及其机制研究

2、肺毒性药物致肺泡上皮细胞损伤的机制研究

学习经历:

    1996/091999/06,苏州医学院/专科生/参与中药化学研究

    2001/092004/06,苏州大学/硕士生/参与中药药理学研究

    2004/092007/06,大连化物所/博士生/参与蛋白质组研究

工作经历:

    1999/08至现在,苏州大学苏州医学院药理学系

发表论文:

1. Mei Zhu, Jian Zhang, Xionghua Sun*, Xihua Chen, Xiaogang Jiang*. Eupafolin suppresses TGF-β1-induced human lung fibroblasts differentiation by downregulating β-catenin/plasminogen activator inhibitor-1 signaling. Pharmacological Research-Modern Chinese Medicine, 2022, 2, 100056.

2. Meng Li, Yadong Cui,Mei Zhu, Xiaolei Huang, Faiz UrRehmana, Jingwen Wang, Lixiao Zhang, Tianwen Liu, Jiangyun Liu, Junye Lu, Xiaogang Jiang*, Jian Zhang*. Isolation and characterization of secondary metabolites from the leaves of Sauropus spatulifolius Beille and their potential biological assays. Fitoterapia. 2022, 156, 105100.

3. Xiafang Xu, Xionghua Sun, Xuelei Wan, Xihua Chen, Xiaogang Jiang*. Mitomycin induces alveolar epithelial cell senescence by down-regulating GSK3β signaling. Toxicology Letters, 2021, 352, 61-69.

4. 朱含月,朱媚,陈喜华,蒋小岗*. 蓝萼甲素下调GSK3β/β-catenin信号通路抑制TGF-β1诱导的肺成纤维细胞转化. 药学学报, 202156, 2950-2956.

5. Xionghua Sun, Mei Zhu, Xihua Chen, Xiaogang Jiang*.MYH9 inhibition suppresses TGF-β1-stimulated lung fibroblast-to-myofibroblast differentia-

tion.Frontiers in Pharmacology,2021, 11, 573524.

6. Xionghua Sun, Xinjian Cui, Xihua Chen, Xiaogang Jiang*.Baicalein alleviated TGF β1-induced type I collagen production in lung fibroblasts via downregulation of connective tissue growth factor. Biomedicine &  Pharmacotherapy,2020, 131, 110744.

7. Fanqing Lu, Xionghua Sun, Xiafang Xu, Xiaogang Jiang*.SILAC-based proteomic profiling of the suppression of TGF-β1-induced lung fibroblast-to-myofibroblast differentiation by trehalose. Toxicologyand Applied Pharmacology, 2020, 391, 114916.

8. Xinjian Cui, Xionghua Sun, Fanqing Lu, Xiaogang Jiang*. Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21. Toxicologyand Applied Pharmacology,2018, 358, 35-42.

9. Xiang Zhou, Xionghua Sun, Xiaogang Jiang*. Comparative proteome profiling of bleomycin-induced lung toxicity in rats by 2D-nano-LC-MS/MS and spectral counting. Biomedical Chromatography, 2017, 31e3857.

10. Xionghua Sun, Xiaogang Jiang*.Automated platform of μLC-MS/MS using SAX trap column for highly efficient phosphopeptide analysis. Analytical and Bioanalytical Chemistry,2017, 409, 2489-2493.

11. 周艳卿,蒋小岗*. Edman降解中异硫氰酸苯酯新修饰位点的发现和验证. 色谱, 2016, 34, 752-756.

12. Yan Gao, Jia Lu, Yu Zhang, Yafen Chen, Zhenlun Gu, Xiaogang Jiang*. Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21. Pulmonary Pharmacology & Therapeutics, 2013, 26, 649-654.

13. Xionghua Sun, Xiaogang Jiang*.Combination of FASP and fully automated 2D-LC-MS/MS allows in-depth proteomic characterization of mouse zymogen granules. Biomedical Chromatography, 2013, 27, 407-408.