陈华兵

发布者:金雪明发布时间:2018-12-04浏览次数:10243

  


    名:陈华兵

    务:博士,特聘教授,博士生导师

国家自然科学基金杰出青年基金获得者(2021年)

国家自然科学基金优秀青年基金获得者(2014年)

江苏省双创计划获得者(2014年)

联系电话:18094258118

电子邮箱:chenhb@suda.edu.cn

办公地址:苏州大学独墅湖校区云轩楼1331

   

一、学习工作经历

1、学历背景:

1997.09-2001.07 华中科技大学,化学与化工学院,精细化工,本科

2001.09-2004.07 华中科技大学,化学与化工学院,无机化学,硕士

2005.09-2008.07 华中科技大学,生命科学与技术学院,生物制药工程博士


2、国外学习研究经历:

2008.08-2010.12 德克萨斯大学西南医学中心,高金明教授实验室,博士后

2010.12-2012.02 东京大学,材料工程系Kataoka教授研究室,博士后


3、工作经历:

2012.03-至今  苏州大学,药学院“纳米药物与分子影像”研究室,负责人

2018.09-至今  苏州大学,放射医学与辐射防护国家重点实验室,学术带头人

2022.01-至今  苏州大学,药学院,副院长


二、研究方向

1、肿瘤靶向纳米药物:构建多功能、靶向性、智能化的纳米载药系统,通过增强药物输送效率、调控肿瘤微环境及免疫微环境、探索协同增效新机制等,实现肿瘤高效协同治疗(如光治疗与化疗、免疫治疗及放疗等的协同治疗),为高致死、难治性肿瘤如胰腺癌等的高效治疗提供新策略。
2、高性能纳米影像探针:通过高分子载体的智能化和功能化设计,实现纳米探针对肿瘤的超灵敏、高空间分辨的智能高对比度探测,为肿瘤早期发现及手术精准导航提供新手段。
3、新型纳米制剂技术及临床转化:构建具有临床应用前景的纳米药物载体(如单分子白蛋白纳米粒、胶束、脂质体、纳米晶及纳米乳等)制备技术,开发高效、低毒的纳米药物新制剂,实现创新制剂产品的临床转化。


三、主要成绩及科研教学成果

2012年回国后,建立了“纳米药物与分子影像”研究室,团队现有教授3人、副教授4人及研究生20余人。作为课题负责人,承担了国家自然科学基金杰出青年科学基金(2021年)、优秀青年科学基金(2014年)、面上项目、青年基金、以及江苏省“双创计划(2014年)”、“苏州市高等院校、科研院所紧缺高层次人才引进资助计划”、江苏省333高层次人才培养工程(2018年)等国家及省市项目。作为核心成员,参与了放射医学与辐射防护国家重点实验室、“双创计划(团队)”项目、江苏省“特种医学”优势学科、“江苏省重大神经精神疾病诊疗技术研究重点实验室”等的建设。作为学术骨干,曾参与了国家重大科学研究计划、国家支撑计划等重大项目的研究。在国外工作期间,分别参与了日本大型科研计划FIRST项目和美国NIH纳米医学研究项目等。在教学方面,承担了本科生专业课程《药剂学》、《Pharmaceutics》(全英文)和专业前沿课程《纳米技术与生物医药的变革》等的教学;牵头建设的《药剂学》在线课程被选为江苏省一流课程。为研究生讲授《药学研究进展》、《Modern Pharmaceutics》(全英文)、《Modern Pharmaceutics and Drug Discovery》(全英文)等课程。
    迄今为止,已发表SCI论文60余篇,其中作为通讯作者在Adv. Mater., ACS Nano, Adv. Funct. Mater., Biomaterials, Theranostics, J. Control. Release等杂志上发表论文30余篇,其中影响因子大于10的论文近30篇,ESI高被引论文10余篇。参编十三五规划教材《药剂学》(科学出版社,并列副主编)、以及《纳米药物》、《Bioinspired and Biomimetic Systems for Drug and Gene Delivery》、《Advances in Nanotheranostics II: Cancer Theranostic Nanomedicine》等中英文专著3本,获授权中国发明专利10余项、湖北省科技进步二等奖1项。担任《药学学报》、《Nanomaterials》、《Sci China Chem》、《Sci Bull》及《Asian J Pharm Sci》等期刊青年编委或客座编辑。被选为中国药学会纳米药物专业委员会委员、中国抗癌协会纳米肿瘤学专业委员会常务委员等。


1、代表性论文

66.  B. Liu#, J Jiao#, W Xu, M Zhang, P Cui, Z Guo, Y Deng*, H Chen*, and W Sun*. Highly Efficient far-red/NIR-absorbing neutral Ir(III) complex micelles for potent photodynamic/photothermal therapy. Adv Mater, 2021, 33, 2100795

65.  Z Guo#, H He#, Y Zhang#, J Rao#, T Yang, T Li, L Wang, M Shi, M Wang, S Qiu, X Song, H Ke, and H Chen*. Heavy-atom-modulated supramolecular assembly increases antitumor potency against malignant breast tumors via tunable cooperativity, Adv Mater2021, 33, 2004225.

64.  M He#, T Yang#, Y Wang, M Wang, X Chen, D Ding*, Y Zheng*, H Chen*, Immune checkpoint inhibitor-based strategies for synergistic cancer therapy, Adv Healthc Mater, 2021, 10, 2002104

63.  Z Wang#, Y Wang#, Y Wang#, C Wei, Y Deng, H Chen, J Shen*, H Ke*. Biomineralized iron oxide–polydopamine hybrid nanodots for contrast-enhanced T1-weighted magnetic resonance imaging and photothermal tumor ablation, J. Mater. Chem. B2021, 9, 1781-1786.

62.  H Iqbal, T Yang, T Li, M Zhang, H Ke, D Ding, Y Deng* H Chen*. Serum protein-based nanoparticles for cancer diagnosis and treatment., J Control Release2021, 329, 997-1022.

61.  Y Zhang#, M Shi#, Z Yan#, S Zhang#, M Wang, H Xu, H Li, Y Ying, S Qiu, J Liu*, H Yang, H Chen, H He*, Z Guo*. Ultrastable near-infrared nonlinear organic chromophore nanoparticles with intramolecular charge transfer for dually photoinduced tumor ablation, Adv Healthc Mater2020, 9, 2001042.

60.  Z Yan#, M Wang#, M Shi, Y He, Y Zhang, S Qiu, H Yang, H Chen, H He*, Z Guo*. Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy, J Mater Chem B2020, 8, 6886-6897.

59.  C Li#, J Wang*, Y Wang#, H Gao#, G Wei#, Y Huang#, H Yu#, Y Gan#, Y Wang#, L Mei#, H Chen#, H Hu#, Z Zhang#, Y Jin#. Recent progress in drug delivery, Acta Pharmaceutica Sinica B2019, 9, 1145-1162.

58.  Q Guo, Q Zhu, T Miao, J Tao, X Ju, Z Sun, H Li, G Xu, H Chen, L Han*. LRP1-upregulated nanoparticles for efficiently conquering the blood-brain barrier and targetedly suppressing multifocal and infiltrative brain metastases, J Control Release2019, 303, 117-129.

57.  W Ke#, J Li#, F Mohammed, Y Wang, K Tou, X Liu, P Wen, H Kinoh, Y Anraku, H Chen, K Kataoka, Z Ge*. Therapeutic Polymersome Nanoreactors with Tumor-Specific Activable Cascade Reactions for Cooperative Cancer Therapy, ACS Nano2019, 13, 2357-2369.

56.  H Zhao#, J Xu, W Huang, G Zhan, Y Zhao*, H Chen*, X Yang*. Spatiotemporally light-activatable platinum nanocomplexes for selective and cooperative cancer therapy, ACS Nano2019, 13, 6647-6661.

55.  H Chen#, Z Gu#, H An, C Chen, J Chen, R Cui, S Chen, W Chen, X Chen, X Chen, Z Chen, B Ding, Q Dong, Q Fan, T Fu, D Hou, Q Jiang, H Ke, X Jiang, G Liu, S Li, T Li, Z Liu, G Nie, M Ovais, D Pang, N Qiu, Y Shen, H Tian, C Wang, H Wang, Z Wang, H Xu, J Xu, X Yang, S Zhu, X Zheng, X Zhang, Y Zhao, W Tan*, X Zhang*, Y Zhao*. Precise nanomedicine for intelligent therapy of cancer, Sci China Chem2018, 61, 1503-1552.

54.  X Lv, X Wang, T Li, C Wei, Y Tang, T, Yang, Q Wang, X Yang, H Chen, J Shen*, H Yang*, H Ke*. Rationally designed monodisperse Gd2O3/Bi2S3 hybrid nanodots for efficient cancer theranostics, Small2018, 14, 1802904.

53.  S Ye, J Rao, S Qiu, J Zhao, H He*, Z Yan, T Yang, Y Deng, H Ke, H Yang, Y Zhao, Z Guo*, H Chen*. Rational design of conjugated photosensitizers with controllable photoconversion for dually cooperative phototherapy, Adv Mater2018, 30, 1801216.

52.  Y Tang, T Yang, Q Wang, X Lv, X Song, H Ke, Z Guo, X Huang, J Hu, Z Li, P Yang*, X Yang*, H Chen*. Albumin-coordinated assembly of clearable platinum nanodots for photo-induced cancer theranostics, Biomaterials2018, 154, 248-260.

51.  Y Wang, Y Deng, H Luo, A Zhu, H Ke, H Yang, H Chen*. Light-responsive nanoparticles for highly efficient cytoplasmic delivery of anticancer agents, ACS Nano2017, 11, 12134-12144.

50.  T Yang, H Ke, Q Wang, Y Tang, Y Deng*, H Yang, X Yang, P Yang, D Ling, C Chen, Y Zhao, H Wu*, H Chen*. Bifunctional tellurium nanodots for photo-induced synergistic cancer therapy, ACS Nano2017, 11, 10012-10024.

49.  H Luo, Q Wang, Y Deng, T Yang, H Ke, H Yang, H He, Z Guo, D Yu, H Wu, H Chen*. Mutually synergistic nanoparticles for effective thermo-molecularly targeted therapy, Adv Funct Mater2017, 27, 1702834.

48.  J Li, K Wei, S Zuo, Y Xu, Z Zha, W Ke, H Chen*, Z Ge*. Light-triggered clustered vesicles with self-supplied oxygen and tissue penetrability for photodynamic therapy against hypoxic tumor, Adv Funct Mater2017, 27, 1702108.

47.  R Wen, X Lv, T Yang, Y Li, Y Tang, X Bai, H Ke*, J Shen*, H Chen*. Albumin nanoreactor-templated synthesis of Gd2O3/CuS hybrid nanodots for cancer theranostics, Sci China Mater2017, 60, 554-562 (Invited paper).

46.  T Yang, L Liu, Y Deng, Z Guo, G Zhang, Z Ge*, H Ke*, H Chen*. Ultrastable near-infrared conjugated polymer nanoparticles for dually photoactive tumor inhibition, Adv Mater2017, 29, 1700487.

45.  M Zhang, L Xing, H Ke, Y He, P Cui, Y Zhu, G Jiang, J Qiao, N Lu, H Chen*, H Jiang*. MnO2-based nanoplatform serves as drug vehicle and MRI contrast agent for cancer theranostics, ACS Appl Mater Interfaces2017, 9, 11337-11344.

44.  H He, S Ji, Y He, A Zhu, Y Zou, Y Deng, H Ke, H Yang, Y Zhao*, Z Guo*, H Chen*. Photoconversion-tunable fluorophore vesicles for wavelength-dependent photo-induced cancer therapy, Adv Mater2017, 29, 1606690.

43.  T Yang, Y Tang, L Liu, X Lv, Q Wang, H Ke, Y Deng, H Yang, X Yang, G Liu, Y Zhao, H Chen*. Size-dependent Ag2S nanodots for second near-infrared fluorescence/photoacoustics imaging and simultaneous photothermal therapy. ACS Nano2017, 11, 1848–1857.

42.  L Zhou, T Yang, J Wang, Q Wang, X Lv, H Ke, Z Guo, J Shen, Y Wang*, C Xing*, H Chen*. Size-tunable Gd2O3@albumin nanoparticles conjugating Chlorin e6 for magnetic resonance imaging-guided photo-induced therapy. Theranostics2017, 7, 764-774.

41.  Y Deng, L Huang, H Yang*, H Ke, H He, Z Guo, T Yang, A Zhu, H. Wu*, H Chen*. Cyanine-anchored silica nanochannels for light-driven synergistic thermo-chemotherapy. Small2017, 13, 1602747.

40.  J Li, X He, Y Zou, D Chen, L Yang, J Rao, H Chen, M Chan, L Li, Z Guo, L Zhang*, C Chen. Mitochondria-targeted platinum(II) complexes: dual inhibitory activities on tumor cell proliferation and migration/invasion via intracellular trafficking of beta-catenin. METALLOMICS2017, 9, 726-733.

39.  S Song, H Shen*, T Yang, L Wang, H Fu, H Chen, Z Zhang*. Indocyanine green loaded Magnetic Carbon Nanoparticles for Near Infrared Fluorescence/Magnetic Resonance Dual-modal imaging and photothermal therapy of tumor. ACS Appl Mater Interfaces2017, 9, 9484-9495.

38.  Z Guo, Y Zou, H He, J Rao, S Ji, X Cui, H Ke, Y Deng, H Yang, C Chen, Y Zhao, H Chen*. Bifunctional platinated nanoparticles for photo-induced tumor ablation. Adv Mater2016, 28, 10155-10164.

37.  T Yang, Y Wang, H Ke, Q Wang, X Lv, H Wu, Y Tang, X Yang, C Chen, Y Zhao, H Chen*. Protein nanoreactor-assisted synthesis of semiconductor nanocrystals for efficient cancer theranostics. Adv Mater2016, 28, 5923-5930.

36.  X An, A Zhu, H Luo, H Ke, H Chen*, Y Zhao*. Rational design of multi-stimuli-responsive nanoparticles for precise cancer therapy. ACS Nano2016, 10, 5947-5958.

35.  Y Ma, J Huang, S Song, H Chen*, Z Zhang*. Cancer-targeted nanotheranostics: recent advances and perspectives. Small2016, 12, 4936-4954.

34.  X Ai, C Ho, J Aw, A Attia, J Mu, Y Wang, X Wang, Y Wang, X Liu, H Chen, M Gao, X Chen, E Yeow, G Liu, M Olivo, B Xing*. In vivo covalent cross-linking of photo-converted rare-earth nanostructures for tumor localization and theranostics. Nat Commun2016, 7, 10432.

33.  Y Li, Y Deng, X Tian, H Ke*, M Guo, A Zhu, T Yang, Z Guo, Z Ge, X Yang, H Chen*. Multi-pronged design of light-triggered nanoparticles to overcome cisplatin resistance for efficient ablation of resistant tumor. ACS Nano2015, 9, 9626-9637.

32.  A Zhu, K Miao, Y Deng, H Ke, H He, T Yang, M Guo, Y Li, Z Guo, Y Wang, X Yang, Y Zhao*, H Chen*. Dually pH/reduction-responsive vesicles for ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. ACS Nano2015, 9,7874-7885.

31.  Y Wang, T Yang, H Ke, A Zhu, Y Wang, J Wang, J Shen, G Liu, C Chen, Y Zhao, H Chen*. Smart albumin-biomineralized nanocomposites for multimodal imaging and photothermal tumor ablation. Adv Mater2015, 27, 3874-3882.

30.  J Huang, M Guo, H Ke, C Zong, B Ren*, G Liu, H Shen, Y Ma, X Wang, H Zhang, Z Deng, H Chen*, Z Zhang*. Rational design and synthesis of γFe2O3@Au magnetic gold nanoflowers for efficient cancer theranostics. Adv Mater2015, 27, 5049-5056.

29.  M Guo, J Huang, Y Deng, H Shen, Y Ma, M Zhang, A Zhu, Y Li, H He, Y Wang, X Yang, Z Zhang*, H Chen*. pH-responsive cyanine-grafted graphene oxide for fluorescence resonance energy transfer-enhanced photothermal therapy. Adv Funct Mater2015, 25, 59-67.

28.  J Li, Z Lyv, Y Li, H Liu, J Wang, W Zhan, H Chen*, H Chen*, X Li*. A theranostic prodrug delivery system based on Pt(IV) conjugated nano-graphene oxide with synergistic effect to enhance the therapeutic efficacy of Pt drug. Biomaterials2015, 51, 12-21.

27.  H Chen, L Xiao, Y Anraku, P Mi, X Liu,H Cabral, A Inoue, T Nomoto, A Kishimura*, N Nishiyama*, K Kataoka*. Polyion complex vesicles for photo-induced intracellular delivery of amphiphilic photosensitizer. J Am Chem Soc2014, 136, 157-163.

26.  M Guo, H Mao, Y Li, A Zhu, H He, H Yang, Y Wang, X Tian, C Ge, Q Peng, X Wang, X Yang, X Chen, G Liu*, H Chen*. Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials2014, 35, 4656-4666.

25.  Z Wan, H Mao, M Guo, Y Li, A Zhu, H Yang, H He, J Shen, L Zhou, Z Jiang, C Ge, X Chen, X Yang, G Liu, H Chen*. Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication. Theranostics2014, 4, 399-411.

24.  H Liu#, Y Li#, Z Lyu#, Y Wan, X Li, H Chen, H Chen, X Li*. Enzyme-triggered supramolecular self-assembly of platinum prodrug with enhanced tumor-selective accumulation and reduced systemic toxicity. J Mater Chem B2014, 2, 8303-8309.

23.  H Yang, H Mao, Z Wan, A Zhu, M Guo, Y Li, X Li, J Wan, X Yang, X Shuai, H Chen*. Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials2013, 34, 9124-9133.

22.  G Huang#, H Chen#, Y Dong#, X Luo, H. Yu, ZMoore, E Bey, D Boothman*, J Gao*. Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy. Theranostics2013, 3,116-126.

21.  H Zhu, J Hao, H Chen, S Jiang, M Liu, H Sun, H Xu, J Zhang, X Yang*. Nanovesicles system for rapid-onset sublingual delivery containing sodium tanshinone IIA sulfonate: In vitro and in vivo evaluation. J Pharm Sci-us2013, 102,2332-2340.

20.  H Chen, H Zhu, J Hu, Y Zhao, Q Wang, J Wan, Y Yang, H Xu, X Yang*. Highly compressed assembly of deformable nanogels into nanoscale suprastructures and their application in nanomedicine. ACS Nano2011, 5, 2671-2680.

19.  H Chen, C Khemtong, X Yang, X Chang, J Gao*. Nanonization strategies for poorly water-soluble drugs. Drug Discov Today2011, 16, 354-360.

18.  D Mou, H Chen, J Wan, H Xu, X Yang*. Potent dried drug nanosuspensions for oral bioavailability enhancement of poorly soluble drugs with pH-dependent solubility. Int J Pharm2011, 413, 237-224.

17.  W Xiong, W Wang, Y Wang, Y Zhao*, H Chen, H Xu, X Yang. Dual temperature/pH-sensitive drug delivery of poly(N-isopropylacrylamide-co-acrylic acid) nanogels conjugated with doxorubicin for potential application in tumor hyperthermia therapy. Colloids Surf B2011, 84, 447-453.

16.  L Xiao, X Xiong, X Sun, Y Zhu, H Yang, H Chen, L Gan*, H Xu, X Yang*. Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles. Biomaterials2011, 32, 447-453.

15.  H Chen, L Xiao, D Du, D Mou, H Xu, X Yang*. A facile construction strategy of highly stable nanoparticles for drug delivery using a hydrogel-thickened microemulsion system as a template. Nanotechnology2010, 21, 5148-5157.

14.  C Mao, J Wan, H Chen, H Xu, X Yang*. The composition of oil phase modulates venous irritation of lipid emulsion-loaded diallyl trisulfide. Drug Development and Industrial Pharmacy2010, 36, 698-704.

13.  E Blanco, E A Bey, C Khemtong, S-G Yang, J Setti-Guthi, H Chen, C W Kessinger, K A CarnevaleW G Bornmann*, D A Boothman, J Gao*. β-Lapachone micellar nanotherapeutics for non–small cell lung cancer therapy. Cancer Res2010, 70, 3896-3904.

12.  H Chen, H Zhu, J Zheng, D Mou, J Wan, J Zhang, T Shi, Y Zhao, H Xu, X Yang*. The iontophoresis-driven penetration of lecithin-based nanovesicles through microneedle-induced skin microchannels for transdermal delivery of insulin. J Control Release2009, 139, 63-72.

11.  C Mao, J Wan, H Chen, H Xu, X Yang*. Emulsifiers’ composition modulates venous irritation of the nanoemulsions as a lipophilic and venous irritant drug delivery system. AAPS PharmSciTech2009, 10, 1058.

10.  H Chen, J Wan, Y Wan, D Mou, H Liu, H Xu, X Yang*. A facile nanoaggregation strategy for oral delivery of hydrophobic drug by utilizing acid-base neutralization reaction. Nanotechnology2008, 19, 375104.

9.  L Xu, H Chen, H Xu, X Yang*. Anti-tumour and immuno-modulation effects of triptolide-loaded polymeric micelles. Eur J Pharm Biopharm2008, 70, 741-748.

8.  D Mou, H Chen*, D Du, C Mao, J Wan, H Xu, X Yang*. Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. Int J Pharm2008, 353, 270-276.

7.  H Chen, D Mou, D Du, X Chang, D Zhu, J Liu, H Xu, X Yang*. Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration. Int J Pharm2007, 341, 78-84.

6.  J Liu, W Hu, H Chen, Q Ni, H Xu, X Yang*. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int J Pharm2007, 328, 191-195.

5.  H Chen, X Chang, D Du, W Liu, J Liu, T Weng, Y Yang, H Xu, X Yang*. Podophyllotoxin-loaded Solid lipid nanoparticles for epidermal targeting. J Control Release2006, 110, 296-306.

4.  H Chen, X Chang, D Du, J Li, H Xu, X Yang*. Microemulsion-based hydrogel formulation of ibuprofen for topical delivery. Int J Pharm2006, 315, 52-58.

3.  X Chang, H Chen, X Zhao, Z Gao, H Xu, X Yang*. High-performance liquid chromatography determination of triptolide in vitro permeation studies. Analytica Chimica Acta2005, 534, 215-221.

2.  H Chen, X Chang, T Weng, X Zhao, Z Gao,Y Yang, H Xu, X Yang*. A study of microemulsion systems for transdermal delivery of triptolide. J Control Release2004, 98, 427-436.

1.  Solid lipid nanoparticle and microemulsion for topical delivery of triptolide. Eur J Pharm Biopharm2003, 56, 189-196.


2、代表性专著

1) 参编《药剂学》(科学出版社,副主编),2017

2) H. T. Ke,H. B. Chen. Chapter 10 - Multimodal Micelles for Theranostic Nanomedicine. Advances in Nanotheranostics II: CancerTheranostic Nanomedicine. Springer-Verlag, Singapore, 2016.

3) H. B. Chen, Z Ge, K Kataoka. Chapter 4 - Polymeric Micelles for Cancer-Targeted Drug Delivery. Bioinspired and Biomimetic Systems for Drugand Gene Delivery. Chemical Industry Press and Wiley-VCH Verlag GmbH &Co. KGaA, Germany, 2015.


3、获授权中国发明专利

1)陈华兵、邓益斌、杨红、柯亨特、刘玲、李厅、杨涛、王璐,一种抗肿瘤铂类药物矿化蛋白纳米粒及其制备方法和应用,ZL201910780919.X

2)郭正清、何慧、陈华兵、杨红、饶佳明、史梦柯、王孟雅、应宇辰、张韶,多碘修饰的氟硼二吡咯类衍生物及其制备方法和应用,ZL201910299092.0

3)杨红、刘迪、陈华兵、邓安平、吕小燕、王雪、李明、姚枫枫、付佩、徐新早、徐涛  靶向光热治疗联合免疫治疗抗肿瘤复合制剂的制备方法, ZL201910483092.6

4)郭正清、饶佳明、何慧、陈华兵、杨红、史梦柯、王孟雅,纳米光敏剂及其制备方法和应用,ZL201811302450.0

5陈华兵、杨红、柯亨特、吕小燕、邓益斌、王雪、杨涛、李明、徐涛,具有近红外光热效应和多模态成像功能的超小蛋白复合纳米粒及其制备方法和应用ZL201710829251.4

6陈华兵、郭正清、邹烨璘、何慧、邓益斌、柯亨特、杨红、饶佳明,一种铂基化氟硼二吡咯类化合物及制备方法和应用,ZL201610846899.8

7)杨红;刘迪; 陈华兵; 邓安平; 吕小燕; 王雪; 李明; 姚枫枫; 付佩; 徐新早; 徐涛, 靶向光热治疗联合免疫治疗抗肿瘤复合制剂及其制备方法与应用, ZL201610690276.6

8陈华兵、杨涛、邓益斌、汪勇、柯亨特、郭正清、何慧、杨红、邹烨璘、计双双、汪巧莉,具有近红外光热效应的铜基人血白蛋白纳米复合物及其制备方法,ZL201510566206.5

9陈华兵、邓益斌、杨红、柯亨特、黄丽、朱爱军、郭正清,具有近红外光热和体内荧光成像特点的多功能介孔二氧化硅纳米粒及其制备方法和应用,ZL201510490341.6

10郭正清、陈华兵、邹烨璘、何慧、饶佳明,近红外吸收的光动力活性的铂类化合物、制备方法及其应用,ZL201510622798.82017年授权

11杨红、陈华兵、吴秀凤、刘洪月、龚珠萍、顾艳、赵成龙、姚枫枫,一种咪喹莫特泡囊凝胶剂及其制备方法,ZL201310141128.5

12杨红、刘洪月、陈华兵、冒华健、韩楠楠、顾睿南、马雪莹、武艺静,一种叶酸修饰去甲斑蝥素隐形泡囊及其制备方法,ZL201310205438.9

13杨祥良、牟东升、周小顺、万江陵、陈华兵、徐辉碧,一种伊曲康唑纳米结晶及其制备方法和应用,2012.08CN200910063819.1

14杨祥良、祝红达、陈华兵、徐辉碧、张介眉、郝建军,口腔粘膜给药的小葱提取物纳米乳药物组合物及其制法,2012.09CN200910273099.1

15陈华兵、杨祥良、徐辉碧、杨亚江、刘卫、周小顺,具有皮肤靶向性的药物组合物及其制备方法和用途, ZL200410013282

16杨祥良,徐辉碧,刘卫,唐琛霞,陈华兵,周小顺,大蒜素注射乳剂及其制备方法, ZL200410060815.5


4、主要承担的科研、人才项目

1)主持国家自然科学基金杰出青年科学基金项目“生物医用高分子材料”(52125304),2022-2026

2)主持国家自然科学基金面上项目“用于肿瘤光动力/光热协同治疗的低氧依赖性聚合物囊泡研究”(51873143),2019-2022

3)主持国家自然科学基金面上项目“铂类药物蛋白纳米粒的仿生合成及在耐药肿瘤协同治疗中的应用”(31671016),2017-2020

4)江苏省高等学校自然科学研究重大项目“铂类药物白蛋白纳米粒的研究”(17KJA350003),2017-2020

5主持国家自然科学基金优秀青年科学基金项目“药物载体”(31422021),2015-2017

6)主持国家自然科学基金面上项目“用于肿瘤光热/分子靶向双向协同治疗的聚合物胶束研究”(51473109),2015-2018

7)主持江苏省“双创人才”项目,2015-2017

8)主持国家自然科学基金青年科学基金项目“用于肝转移瘤早期探测的可激活近红外荧光纳米探针研究”(81202472),2013-2015

9)主持“苏州市高等院校、科研院所紧缺高层次人才引进资助计划”,2014-2018

10)主持湖北省科技攻关项目“鬼臼毒素微乳凝胶剂的研制”(2005AA301B10),  2005-2007

11)参与江苏省“特种医学”优势学科项目(PAPD),2015-2018

12)参与江苏省“双创计划(团队)”项目,2015-2017

13)参与“江苏省重大神经精神疾病诊疗技术研究重点实验室”建设项目,2014-2016

14)参与国家重大研究计划课题“新型导向性纳米药物载体的构建及表征 (2006CB933301),2006-2008


四、主要荣誉

12021年国家自然科学基金杰出青年科学基金

22018年江苏省333高层次人才培养工程(第三层次)

32016年中国药物制剂大会青年药剂学奖

42014年国家自然科学基金优秀青年科学基金

52014年江苏省“双创人才”

62014年苏州市高等院校、科研院所紧缺高层次人才


五、其它

本课题组现招收或联合培养有志从事科研工作的硕、博士研究生,并欢迎感兴趣的高年级本科生到课题组实习。欢迎具有药学、化学、材料、或生物学背景的同学报考。

联系方式:chenhb@suda.edu.cn,通讯地址:江苏省苏州市苏州工业园区仁爱路199号苏州大学药学院云轩楼1331室(邮编:215123)