张真庆

姓名：张真庆

职称：苏州大学特聘教授，江苏特聘教授

联系电话：0512-65882593

电子邮箱：z_zhang@suda.edu.cn

办公地址：苏大独墅湖校区2期云轩楼1129

张真庆教授简介

一、学习工作经历

1、学历背景

1996.09 - 2000.06：中国海洋大学，药学

2000.09 - 2006.06：中国海洋大学，工学博士，研究方向糖科学

2、工作经历

2006.08 - 2009.09：美国Rensselaer Polytechnic Institute, 博士后

2009.10 –2012.08：美国Baxter Healthcare,研究员

2012.08 – 目前：  苏州大学药学院，教授

二、研究方向

1、糖药物结构、制备工艺、质量控制

2、糖药物-免疫学构效关系研究

3、糖药物-神经退行性疾病构效关系研究

4、肝素类药物糖组学研究

5、抗体药物糖基化研究发

三、主要研究成果

1、论文

(1) J. Hao, F. Wu, R. Tang, Y. Sun, D. Liu,^*Z. Zhang^a* Preparation of 1,4-linked α-D-glucuronans from starch with 4-acetamide-TEMPO/NaClO2/NaClO system,  International Journal of Biological Macromolecules,2020 in press. 2区, IF4.8

(2)D. Bi, X. Li, T. Li, X. Li, Z. Lin, L. Yao, H. Li, H. Xu, Z. Hu, Z. Zhang*, Q. Liu* and X Xu* Characterization and Neuroprotection Potential of Seleno-Polymannuronate, Frontiers in Pharmacology, 2020,11: 21, 2区，IF3.8

(3)Y. Meng, L. Yi, L. Chen, J. Hao, D. Li, J. Xue*, N. Xu, Z.Zhang*. Purification, structure characterization and antioxidant activity of polysaccharides from Saposhnikovia divaricate, Chinese Journal of Natural Medicines.2019, 17(10): 0792-0800, 4区，IF:  1.991

(4)Y. Ouyang, M. Zhu, X.Wang, L. Yi, Y. Yao, J. Fareed, R. J Linhardt*, Z. Zhang,*Systematic analysis of enoxaparins from different sources with online one and two-dimensional chromatography, Analyst. 2019, 144, 3746-3755. 2区，IF 4.019

(5)Y. Ouyang, Y. Yu, F. Zhang, J. Chen, X. Han, K. Xia, Y.Yao, Z. Zhang,* R.J. Linhardt*, Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications, Journal Medicinal Chemistry, 2019, 62, 1067-1073. 2区，IF 6.054.

(6)Y. Ouyang, X. Han, Q. Xia, J. Chen, S. Velagapudi, K. Xia,Z. Zhang^* and R.J Linhardt^* Negative-ion Mode Capillary Isoelectric Focusing-Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides, Analytical Chemistry, 2019, 91, 846-853. 1区，IF 6.35

(7)R. Cheng, X. Tang, A. Long, J. Mwangi, R. Lai, R. Sun, C. Long, Z. Zhang^*. Purification and characterization of a novel anti-coagulant from the leech Hirudinaria manillensis. Zoological Research. 2019, 40(3): 205-210.

(8)F. Wu，K. Dong, M. Zhu, Q. Zhang, B. Xie, D. Li, H.Gan, Z. Zhang* Development of a method to analyze the complexes of enoxaparin and plateletfactor 4 with size-exclusion chromatography, Jounral of Pharmaceutical and Biomedical Analysis, 2019, 164, 668-671. 3区，IF 2.983

(9)Y. Ouyang, X. Han, Y. Yu, J. Chen, L. Fu, F. Zhang, R. Linhardt, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta, Z. Zhang,* K. Xia*. Chemometric analysis of porcine, bovine and ovine heparins, Jounral of Pharmaceutical and Biomedical Analysis, 2019, 164, 345-352. 3区，IF 2.983

(10)Y. Lin, Q. Zhang, Y. Meng, J. Hao, B. Xie, H. Gan, D. Li, K. Dong, Z. Zhang*  Qualitative and quantitative analysis of 2, 5-anhydro-D-mannitol in low molecular weight heparins with high performance anion exchange chromatography hyphenated quadrupole time of flight mass spectrometry, Journal of Chromatography A. 2018, 1569:160-167. 2区，IF 3.858

(11)Z. Liu, Y. Xiong, L. Yi, R. Dai, Y. Wang, M. Sun, X. Xiao, Z. Zhang*, S. Yuan*, Endo-β-1,3-glucanase digestion combined with the HPAEC-PAD-MS/MS analysis reveals the structural differences between two laminarins with different bioactivities, Carbohydrate Polymers, 2018, 194, 339-349. 2区，IF: 6.044

(12)R. Tang¹, J. Hao¹, R.Zong, F. Wu, Y. Zeng, Z. Zhang*, Oxidation pattern of curdlan with TEMPO-mediated system, Carbohydrate Polymers, 2018, 186, 9-16. 2区，IF: 6.044

(13)Y. Ouyang, Y. Zeng, L. Yi, H. Tang, D. Li, R. Linhardt, Z. Zhang* Qualitative and quantitative analysis of heparin and low molecular weight heparins using size exclusion chromatography with multiple angle laser scattering/refractive index and inductively coupled plasma/mass spectrometry detectors, Journal of Chromatography A. 2017, 1522(3): 56-61, 2区，IF 3.858

(14)L. Xu, Z. Zhang*, X. Sun, J. Wang, W. Xu, L. Shi, J. Lu, J. Tang, J. Liu, X. Su.Glycosylation status of bone sialoprotein and its role in mineralization, Exp Cell Res. 2017 (17):30514-1. 2区，IF 3.329

(15)Y. Rong, N Xu, B Xie, J Hao, L Yi, R Cheng, D Li, R. J. Linhardt, Z. Zhang,* Sequencing analysis of β-glucan from highland barley with high performance anion exchange chromatography coupled to quadrupole time – of – flight mass spectrometry, Food Hydrocolliods,2017, 73, 235-242. 2区，IF: 5.839

(16)X. Sun, L. Tao, L. Yi, Y. Ouyang, N. Xu, D. Li, R. Linhardt, Z. Zhang* N-glycans released from glycoproteins using a commercial kit andcomprehensively analyzed with a hypothetical database, Journal of Pharmaceutical Analysis, 2017, 7(2): 87-94.  IF: 4.44

(17)L. Tao, F. Song, N. Xu, D. Li, R.J. Linhardt, Z. Zhang* New Insights into the Action of Bacterial Chondroitinase AC I and Hyaluronidase on Hyaluronic Acid, Carbohydrate Polymers, 2017, 158: 85-92.2区，IF: 6.044

(18)J. Hao, S. Xu, N. Xu, D. Li, R.J Linhardt, Z. Zhang*  Impact of Degree of Oxidation on the Physicochemical Properties of Microcrystalline Cellulose Carbohydrate Polymers, 2017, 155, 483-490.2区，IF: 6.044

(19)J. Hao, J. Lu, N. Xu, R. J. Linhardt, Z. Zhang^*Specific oxidation pattern of soluble starch with TEMPO-NaBr-NaClO system, Carbohydrate Polymers, 2016, 146:238-244, 2区，IF: 6.044

(20)Y. Ouyang, C. Wu, X. Sun, J. Liu, R. J. Linhardt, Z. Zhang*. Development of Hydrophilic-Interaction-Chromatography with Quadruple-Time-of-Flight Mass Spectrometry for Heparin and Low-Molecular-Weight-Heparin Disaccharide Analysis, Rapid communications in mass spectrometry, 2016,30,277-284. 4区，IF: 2.045

(21)L. Yi, Y. Ouyang, X. Sun,N. Xu, R. J. Linhardt, Z. Zhang* Qualitative and quantitative analysis of branches in dextran using high-performance anion exchange chromatography coupled to quadrupole time-of-flight mass spectrometry, Journal of Chromatography A., 2015, 1423:79-85. 2区，IF 3.858

(22)Y. Ouyang, Y. Zeng, Y. Rong, Y. Song, L. Shi, B. Chen, X. Yang, N. Xu, R. J. Linhardt, Z. Zhang* Profiling Analysis of Low Molecular Weight Heparins by Multiple Heart-Cutting Two Dimensional Chromatography with Quadruple Time-of-Flight Mass Spectrometry, Analytical Chemistry, 2015, 87(17): 8957-8963. 1区，IF 6.35

(23)C. Wu, J. Liu, Z. Zhang^* Hydrophilic interaction liquid chromatography- quadrupole-time-of-flight mass spectrometry analysis of glycosaminoglycan oligosaccharides, Chinese Journal of Analytical Chemistry, 2015, 43(8):1198-1202.4区，IF: 0.931

(24)L. Yi, X Sun, K. Du, Y. Ouyang, C. Wu, N. Xu, R. J. Linhardt, Z. Zhang*, UP-HILIC-MS/MS to Determine the Action Pattern of Penicillium sp. Dextranase, Journal of American Society for Mass Spectrometry, 2015, 26, 1174-1185. 3区，IF: 3.202

(25)J. Lu, H. Yang, J. Hao, C. Wu, L. Liu, N. Xu, R. J. Linhardt, Z. Zhang*, Impact of hydrolysis conditions on the detection of mannuronic to guluronic acid ratio in alginate and its derivatives,Carbohydrate Polymers, 2015, 122, 180–188, 2区，IF: 6.044

(26)Z. Zhang, S. Till,  S. Knappe, C. Quinn, J. Catarello, G. J. Ray, F. Scheiflinger, C. M. Szabo, M. Dockal*, Screening of Complex Fucoidans from Four Brown Algae Species as Procoagulant Agents Carbohydrate Polymers, Carbohydrate Polymers.2015,115, 677-685, IF: 2区，IF: 6.044

2、已授权专利

1. 不饱和透明质酸奇数寡糖及其制备方法，CN201611020047.X，排名1

2. 一种氧化型β-1,4-寡聚葡萄糖醛酸及其制备方法和用途，CN201611020047.X，排名1

3. 一种氧化型α-1,4-寡聚葡萄糖醛酸及其制备方法和用途，201510267211.6，排名1

4. Factor VIII half-life extension by polysialic acid，13/803,594，排名2

5. Drug candidate screening and structure-activity relationship of a non-anticoagulant sulfated polysaccharide，61/683,144，排名3

3、软件著作

Glycomapping v1.0（This software is patented and its copyright belongs to Soochow University. It is free for research purpose.）

Glycomapping v1.0 Install.zip