马新朋

姓    名：马新朋

职    务：博士，药学院产业教授；艾博生物科技有限公司副总裁

联系电话：18796870682

电子邮箱：lazypony2008@hotmail.com

研究方向：核酸递送系统及其创新制剂的研究与开发

一、工作经历:                                                                

2022.9－至今，苏州大学药学院产业教授、艾博生物科技有限公司副总裁（2022.11起）

2021.8－2022.10，首席科学家、副总裁，哈瑞贝尔医药科技有限公司，苏州，中国

·         建立新型高效的纳米脂质体平台技术，并应用于mRNA药物的开发，目前已经建立了完整的mRNA药物管线。

2020.8－2021.7，首席科学家，亭创生物科技有限公司，上海，中国

·         建立了多条肿瘤诊疗管线，包括高分子纳米示踪剂、多肽靶向示踪剂等，并于2022年申报肿瘤术中导航新药IND；

·         建立了高分子纳米载药平台并应用于多种肿瘤和核酸药物的递送中，计划于2023年申报多个IND。

2016.9－2020.8，高级科学家、项目主管，莫德纳公司，剑桥，马萨诸塞，美国

·         完成莫德纳新冠疫苗的早期研发和质量研究 (mRNA-1273, Spikevax)；

·         完成新型亲水聚合物脂质体复合物和生物可降解高分子材料的研发，并应用于与蛋白替代及与Vertex的合作项目中 (mRNA-0184, VXc-522)；

·         建立新型mRNA递送平台，包括LNP，脂质体-高分子复合纳米制剂，高分子络合物等技术路线 (平台技术)。

2014.9－2016.8，研究科学家，BIND Therapeutics公司，剑桥，马萨诸塞，美国

·         主持设计了靶向双嵌段高分子载药纳米平台，并应用于非小细胞肺癌疗法并进入临床二期；参与开发了高分子载药材料的工艺开发并转移至GMP用于临床三期 (BIND-014, Phase III)；

·         设计开发了超低分散度双嵌段高分子材料PEG-PLA的合成方法及衍生主动靶向聚合物，开发出具有超长效缓释递送平台 (平台技术)。

2011.6－2014.9，博士后，德州大学西南医学中心（合作导师：高金明教授，David Boothman教授），达拉斯，美国

·         研究与开发了酸度响应的超灵敏高分子纳米荧光胶束，并应用于癌症外科手术中实时导航和癌症免疫治疗，该技术已授权给Onconano Medicine, 其中术中导航（ONM-100）已经入二期临床并获得FDA的Fast Track Designation，癌症免疫治疗项目（ONM-501）已完成前临床研究并已经提交IND申请。

·         通过高分子纳米制剂技术解决了小分子靶向抗癌药物β-lapachone溶解性差和生物利用度低的难题，此技术授权给了Systems Oncology并进入临床I/II期；同时，运用前药技术开发了小分子抗癌药β-lapachone的新型纳米制剂。

二、教育经历:                                                                           

2006.9－2011.4，怀俄明大学，化学工程博士（导师：申有青教授），怀俄明州，美国

·         开发了电荷反转脂质体技术并应用于癌症药物的靶向递送；

·         首次实现了连续点击化学技术应用于生物可降解树枝状高分子材料的合成；

·         构建了树枝状高分子聚合物和多个阳离子型高分子聚合物载体系统。

2003.9－2006.7，南开大学，有机化学硕士（导师：赵国锋教授），天津，中国

·         发现了制备硫代磷酰亚胺的新方法并研究了硫代磷酰亚胺的还原反应和不对称加成反应；

1999.9－2003.7，辽宁师范大学，化学学士，大连，中国

三、主要科研成绩及代表性成果:         

马新朋博士擅长利用药学、化学化工、生物医用材料等多学科交叉来解决生物制药领域的基础问题和产业难题，尤其是在mRNA递送系统及其创新制剂的研究与临床转化方面拥有丰富的科研经历。迄今为止已发表近30篇高水平科研论文，他引次数超过2700次，多篇论文发表在Nat. Mater., Nat. Biomed. Eng., Nat. Commun., JACS, Angew, Adv. Mater.等杂志，并被学术媒体大量报道。在美国和中国工作期间，主持开发了大量创新生物药的研发和临床项目，多个产品已经上市或在临床试验阶段。尤其是2020年负责了莫德纳公司mRNA新冠疫苗的早期研发和质量研究 (mRNA-1273, Spikevax)，目前负责艾博生物科技有限公司化学部门，在mRNA疫苗研发领域拥有深厚的产业化经验。

代表性论文：

1.      Yiguang Wang, Chensu Wang, Yang Li, Gang Huang, Tian Zhao, Xinpeng Ma, Zhaohui Wang, Baran D Sumer, Michael A White, Jinming Gao. Digitization of Endocytic pH by Hybrid Ultra‐pH‐Sensitive Nanoprobes at Single‐Organelle Resolution. Adv. Mater., 2017, 29, 1603794.

2.      Tian Zhao, Gang Huang, Yang Li, Shunchun Yang, Saleh Ramezani, Zhiqiang Lin, Yiguang Wang, Xinpeng Ma, Zhiqun Zeng, Min Luo, Esther de Boer, Xian-Jin Xie, Joel Thibodeaux, Rolf A Brekken, Xiankai Sun, Baran D Sumer, Jinming Gao, A transistor-like pH nanoprobe for tumour detection and image-guided surgery. Nat. Biomed. Eng., 2017, 1, 0006-0011.

3.      Qihang Sun, Xinpeng Ma, Bo Zhang, Zhuxian Zhou, Erlei Jin, Youqing Shen, Edward A Van Kirk, William J Murdoch,Maciej Radosz, Weilin Sun. Fabrication of dendrimer-releasing lipidic nanoassembly for cancer drug delivery. Biomater. Sci., 2016, 4, 958-969.

4.      Xinpeng Ma, Zachary R Moore, Gang Huang, Xiumei Huang, David A Boothman, Jinming Gao. Nanotechnology-enabled delivery of NQO1 bioactivatable drugs, J Gao J. Drug Target., 2015, 23, 672-680

5.      Xinpeng Ma, Xiumei Huang, Zachary Moore, Gang Huang, Jessica A. Kilgore, Yiguang Wang, Suntrea Hammer, Noelle S. Williams, David A. Boothman, Jinming Gao. Esterase-Activatable β-Lapachone Prodrug Micelles for NQO1-Targeted Lung Cancer Therapy. J. Controlled Rel., 2015, 200, 201-211.

6.      Bo Zhang*, Xinpeng Ma*, Meihua Sui, Edward A Van Kirk, William J Murdoch, Maceij Radosz, Guanidinoamidized linear polyethyleneimine for gene delivery. Chin. J. Poly. Sci., 2015, 33, 908-919. (* Co-first author)

7.      Chensu Wang, Yiguang Wang, Yang Li, Brian Bodemann, Tian Zhao, Xinpeng Ma, Gang Huang, Zeping Hu, Ralph DeBerardinis, Michael White, and Jinming Gao. A Nanobuffer Reporter Library for Fine-Scale Imaging and Perturbation of Endocytic Organelles. Nat. Commun., 2015, 6, 8524-8534.

8.      Xinpeng Ma, Xiumei Huang, Gang Huang, Longshan Li, Yiguang Wang, Xiuquan Luo, David A Boothman, Jinming Gao. Prodrug Strategy to Achieve Lyophilizable, High Drug Loading Micelle Formulations Through Diester Derivatives of β-Lapachone. Adv. Healthcare Mater., 2014, 3, 1210-1216.

9.      Xinpeng Ma, Yiguang Wang, Tian Zhao, Lee-Chun Su, Yang Li, Gang Huang, Baran D. Sumer, and Jinming Gao. Ultra-pH Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions. J. Am. Chem. Soc., 2014, 136, 11085-11092. (ACS Editor’s choice, highlighted by C&EN)

10.  Yiguang Wang, Kejin Zhou, Gang Huang, Chris Hensley, Xiaonan Huang, Xinpeng Ma, Baran D. Sumer, Ralph J. DeBerardinis, Jinming Gao. Ultra-pH Sensitive Fluorescent Nanoprobes for Tumor Microenvironment Imaging in Living Animals. Nat. Mater.,2014, 13, 204-212.

11.  Xinpeng Ma, Gang Huang, Yiguang Wang, Jinming Gao. Targeted Nanomedicines: Challenges and Opportunities. RSC Polymer Chemistry Series (2013), 3, 20-31.

12.  Qihang Sun, Xuanrong Sun, Xinpeng Ma, Zhuxian Zhou, Erlei Jin, Bo Zhang, Youqing Shen, Edward A Van Kirk, William J Murdoch, Joseph R Lott, Timothy P Lodge, Maciej Radosz, Yuliang Zhao. Integration of nanoassembly functions for an effective delivery cascade for cancer drugs. Adv. Mater., 2014, 26, 7615-7621.

13.  Yang Li, Yiguang Wang, Gang Huang, Xinpeng Ma, Kejin Zhou, Jinming Gao*. Chaotropic-anion-induced supramolecular self-Assembly of ionic polymeric micelles. Angew. Chem. Int. Ed., 2014, 53 (31), 8074-8078.

14.  Ma Xinpeng, Sun Qihang, Zhou Zhuxian, Jin Erlei, Tang Jianbin, Van Kirk Edward, Murdoch William J, Shen Youqing. Synthesis of degradable bifunctional dendritic polymers as versatile drug carriers. Polym. Chem., 2013, 4, 812-819.

15.  Ma Xinpeng, Zhou Zhuxian, Jin Erlei, Sun Qihang, Zhang Bo, Tang Jianbin, Shen Youqing. Facile Synthesis of Polyester Dendrimers as Drug Delivery Carriers. Macromolecules, 2013, 46, 37-42.

16.  Zhuxian Zhou, Xinpeng Ma, Erlei Jin, Jianbin Tang, Meihua Sui, Youqing Shen, Edward A. Van Kirk, William J. Murdoch, Maciej Radosz. Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug deliver.Biomaterials, 2013, 34, 5722-5735.

17.  Bo Zhang, Xinpeng Ma, William Murdoch, Maciej Radosz, Youqing Shen. Bioreducible poly(amido amine)s with different branching degrees as gene delivery vectors. Biotechnol. Bioeng., 2013, 110, 990-998.

18.  Huang Xiaonan, Huang Gang, Zhang Shanrong, Sagiyama Koji, Togao Osamu, Ma Xinpeng, Wang Yiguang, Li Yang, Soesbe Todd C, Sumer Baran D, Takahashi Masaya, Sherry A. Dean, Gao Jinming. Multi-Chromatic pH-Activatable ¹⁹F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes. Angew. Chem. Int. Ed., 2013, 52, 8074-8078.

19.  Jin Erlei, Zhang Bo, Sun Xuanrong, Zhou Zhuxian, Ma Xinpeng, Sun Qihang, Tang Jianbin, Shen Youqing, Van Kirk Edward, Murdoch William, Radosz Maciej. J. Am. Chem. Soc., 2013, 135, 933-940.

20.  Shen Youqing,* Ma Xinpeng, Zhang Bo, Zhou Zhuxian, Sun Qihang, Jin Erlei, Sui Meihua, Tang Jianbin, Wang Jinqiang, Fan Maohong. Degradable Dual pH- and Temperature-Responsive Photoluminescent Dendrimers. Chem.- Eur. J., 2011, 17, 5319-5326.

21.  Zhou Zhuxian, Shen Youqing*, Tang Jianbin, Jin Erlei, Ma Xinpeng, Sun Qihang, Zhang Bo, Van Kirk Edward, Murdoch William. Linear polyethyleneimine-based charge-reversal nanoparticles for nuclear-targeted drug delivery. J. Mater. Chem., 2011, 21, 19114-19123. 

22.  Ma Xinpeng, Tang Jianbin, Shen Youqing, Fan Maohong, Tang Huadong, Radosz Maciej. Facile Synthesis of Polyester Dendrimers from Sequential Click Coupling of Asymmetrical Monomers., J. Am. Chem. Soc., 2009, 131, 14795-14803. (Highlighted by SYNFACTS)

23.  Zhou Zhuxian, Shen Youqing, Tang Jianbin, Jin Erlei, Ma Xinpeng, Sun Qihang, Zhang Bo, Van Kirk Edward, Murdoch William. Linear polyethyleneimine-based charge-reversal nanoparticles for nuclear-targeted drug delivery. J. Mater. Chem., 2011, 21, 19114-19123. 

24.  Hu Kuang, Wang Chungui, Ma Xinpeng, Wang Youming, Zhou Zhenghong, Tang Chuchi. N-Thiophosphoryl imines: convenient substrates in the aza-Henry reaction. Tetrahedron: Asymmetry 2009, 20, 2178-2184.

25.  Xu Xinyuan, Wang Chungui, Zhou Zhenghong, Zeng Zebing, Ma Xinpeng, Zhao Guofeng, Tang Chuchi. A convenient and practical method for the synthesis of N-thiophosphoryl aldimines and ketimines. Heteroat. Chem.,2008, 19, 238-244.

26.  Ma Xinpeng, Xu Xinyuan, Wang Chungui, Zhao Guofeng, Zhou Zhenghong, Tang Chuchi. Distinct chemoselectivity in the reaction of N-(thio)phosphoryl imines with diethylzinc., J. Organomet. Chem., 2007, 692, 3685-3690.

27.  Ma Xinpeng, Wang Chungui, Xu Xinyuan, Zhao Guofeng, Zhou Zhenghong, Tang Chuchi. Reaction between N-(thio)phosphoryl imines and diethylzinc. Lett.Org.Chem., 2007, 4, 51-53.

28.  Xu Xinyuan, Wang Chungui, Zhou Zhenghong, Zeng Zebing, Ma Xinpeng, Zhao Guofeng, Tang Chuchi. A convenient and practical method for the synthesis of aromatic N-thiophosphoryl imines. Lett. Org. Chem., 2006, 3, 640-642.

代表性专利：

1. Gao Jinming, Liu Yuliang, Wei Qi, Ma Xinpeng, Huang Gang, Naphthoquinones, pro-drugs, and methods of use thereof. US Patent 10829427, 2020.

2. Gao, Jinming; Huang, Gang; Zhao, Tian; Ma, Xinpeng; Wang, Yiguang; Li, Yang; Sumer, Baran D.Library of pH responsive polymers and nanoprobes for molecular and cellular biology, cancer imaging, nanotechnology, and fluorescence sensors. PCT Int. Appl. (2015), WO 2015188157 A1 20151210.

3. Hergenrother, Paul J.; Boothman, David A.; Bair, Joseph S.; Cao, Lifen; Gao, Jimming; Huang, Xiumei; Luo, Xiuquan; Ma, Xinpeng; Moore, Zachary R.; Parkinson, Elizabeth I.Tumor-selective novel combination therapy. PCT Int. Appl. (2014), WO 2014168991 A1 20141016.