Meet KIFAYAT ULLAH

发布者:王燕发布时间:2022-08-24浏览次数:19

About Kifayat Ullah

In 2020, Kifayat Ullah received a Master's degree in Pharmacology from the College of Pharmaceutical Sciences, Soochow University. Kifayat’s research explores and discovers a novel molecular mechanism by which the E3 ubiquitin ligase STUB1 attenuates the hydrogen peroxide-induced senescence through promoting the ubiquitination and proteasomal degradation of the master regulator of the circadian clock protein BMAL1. Now Kifayat is a Ph.D. student at Zhejiang University.

Kifayat’s research identified the E3 ligase STUB1 as a new interactor of the master regulator of the circadian clock protein BMAL1 and found that it can reduce the BMAL1 protein level. Further it was explored that overexpression of STUB1 attenuates and knockdown of STUB1 enhances the hydrogen peroxide-induced cellular senescence through regulating the ubiquitination and proteasomal degradation of BMAL1. Restoration of BMAL1 protein level abolishes the effect of STUB1 on cell senescence. These findings may have important implications for the exploration of the pathogenesis and molecular mechanism of cellular senescence. He has published his work as first author in J Biol Chem (research article) and FEBS J (Review, Cover Story).

His thesis was rated as the outstanding Master's thesis in Jiangsu Province. 

 

Testimonial

Before joining Soochow University, I was not much familiar with experimental work but the cooperation of my Chinese labmates and the guidance of my mentor enabled me to perform quality research.

Soochow University's Graduate School of Chinese International Education is the perfect place for international students with both traditional and modern curriculum. I was very satisfied with the kindness and professionalism of the professors, and I was able to learn a lot about Chinese language. Suzhou is definitely an ideal city to learn Chinese culture as well since it has about 2500 years history.