糖药物研究教研室(张真庆 教授)

发布者:王燕发布时间:2020-02-26浏览次数:13




张真庆苏州大学特聘教授,江苏特聘教授,博士生导师(z_zhang@suda.edu.cn

张真庆教授于2000年、2003年、2006年分别获得中国海洋大学药学学士学位、药物化学硕士学位和糖化学博士学位。2006-2009年在美国伦斯勒理工学院进行博士后研究,20092012年在美国百特(Baxter)继续从事糖类药物研究。2012年以江苏特聘教授进入苏州大学药学院任职至今,是江苏省双创引进人才(2013)、江苏省双创团队核心成员(2014)、江苏省六大高峰人才2017)、张天民糖类药物“杰出青年奖”(2021)。

张真庆教授主要从事糖类药物的结构分析及相关活性的构效关系研究。迄今发表SCI论文近百篇,申请专利27项,已获授权13项,一项软件著作。先后主持江苏省特聘教授科研基金、国家自然科学基金项目(面上)等多个项目。

主要研究方向:

1. 糖药物结构、制备工艺、质量控制

2. 糖药物-免疫学构效关系研究

3. 糖药物-神经退行性疾病构效关系研究

4. 肝素类药物糖组学研究

5. 抗体药物糖基化研究

6. 多糖铁剂、多糖纳米载药系统研究

近五年承担的科研项目

1. 国家自然科学基金面上项目81673388),肝素类药物糖组学研究,2017.01-2020.12,主持。

2. 国家自然科学基金面上项目(81473179复杂蛋白聚糖的序列分析,2015.01-2018.12,主持。

3. 江苏省特聘教授科研基金,江苏省科技厅, 2012.11-2015.12,主持。

近五年发表论文

1. N. Yan, F. Song, Y. Ouyang, D. Li, H. Tian, L. Yi*, R. J. Linhardt, Z. Zhang*; Glycan mapping of low-molecular-weight heparin using mass spectral correction based on chromatography fitting with“Glycomapping” software,Analytical Chemistry, 2022, 94: 13000−13009.1,  IF:8.0

2. J. Lu, Q. Pan, J. Zhou, Y. Weng, K. Chen, L. Shi, G. Zhu, C. Chen, L. Li*, M. Geng, Z. Zhang*; Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China,Journal of Pharmaceutical Analysis,2022, 12: 145-155.1,  IF:14.0

3. N. U. Ain , S. Wu , X. Li, D. Li*, Z. Zhang*; Isolation, characterization, pharmacology and biopolymer applications of licorice polysaccharides: review, Materials, 2022, 15: 3654-3676. 1,  IF:3.6

4. L. Chen, W. Zhu, N. Yan, Y. Guo, L. Yi, Y. Ouyang*, Z. Zhang*; Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS, Journal of Pharmaceutical and Biomedical Analysis, 2022, 212:114616-114323. 3,  IF:3.6

5. F. Wu, N. Yan, Y. Guo, X. Yu, L. Yi, Y. Ouyang, X. Wang*, Z. Zhang*; Pattern of Specific Oxidation of Konjac Glucomannan with TEMPO/NaBr/ NaClO system, Carbohydrate Research, 2022, 515: 108558-108566. 3,  IF:4.0

6. W. Zhu, L. Chen, N. Yan, L. Yi, Y. Sun, Y Ouyang, D. Liu, Z. Zhang*; Sequencing analysis of heparin reducing terminals with orthogonal chromatographic approaches, Journal of Chromatography A, 2022, 1677: 463318-463326. 2,  IF:4.6

7. L. Chen; Y. Ouyang; N. Yan; Y. Guo; L. Yi; Y. Sun; D. Liu; Z. Zhang*; Comprehensive analysis of heparinase derived heparin-products using two-dimensional liquid chromatography coupled with mass spectrometry, Journal of Chromatography A, 2021, 1643: 462042-462049. 2,  IF:4.6

8. B. Xie1, L. Yi1, Y. Zhu, X. Chang, J. Hao, L. Pang, Y. Ouyang, S. Yuan, Z. Zhang* Structural elucidation of a novel branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system, Carbohydrate Polymers, 2021, 251: 117080-117091. 1,  IF:10.7

9. P. Qiu, F. Wu, L. Yi, L. Chen,Y. Jin, X Ding, Y. Ouyang, Y. Yao, Y. Jiang, Z. Zhang*, Structure characterization of a heavily fucosylated chondroitin sulfate from sea cucumber (H. leucospilota) with bottom-up strategies, Carbohydrate Polymers, 2020, 240, 116337. 1,  IF:10.7

10. J. Hao, F. Wu, R. Tang, Y. Sun, D. Liu*, Z. Zhang* Preparation of 1,4-linked α-D-glucuronans from starch with 4-acetamide-TEMPO/NaClO2/NaClO system,  International Journal of Biological Macromolecules,2020, 151:740-746. 2,  IF:8.0

11. D. Bi, X. Li , T. Li, X. Li, Z. Lin, L. Yao, H. Li, H. Xu, Z. Hu, Z. Zhang*, Q. Liu* and X Xu* Characterization and Neuroprotection Potential of Seleno-Polymannuronate,Frontiers in Pharmacology, 2020,11: 21, 2区,IF:6.0

12. Y. Meng, L. Yi, L. Chen, J. Hao, D. Li, J. Xue*, N. Xu, Z.Zhang*. Purification, structure characterization and antioxidant activity of polysaccharides from Saposhnikovia divaricate, Chinese Journal of Natural Medicines.2019, 17(10): 0792-0800, 4IF:  3.9

13. Y. Ouyang, M. Zhu, X.Wang, L. Yi, Y. Yao, J. Fareed, R. J Linhardt*, Z. Zhang,* Systematic analysis of enoxaparins from different sources with online one and two-dimensional chromatography, Analyst.2019, 144, 3746-3755.2区,IF:5.2

14. Y. Ouyang, Y. Yu, F. Zhang, J. Chen, X. Han, K. Xia, Y.Yao, Z. Zhang,* R.J. Linhardt*, Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications, Journal of Medicinal Chemistry, 2019, 62, 1067-1073.2区,IF:8.0.

15. Y. Ouyang, X. Han, Q. Xia, J. Chen, S. Velagapudi, K. Xia,Z. Zhang* and R.J Linhardt* Negative-ion Mode Capillary Isoelectric Focusing-Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides, Analytical Chemistry, 2019, 91, 846-853. 1区,IF:8.0

16. R. Cheng, X. Tang, A. Long, J. Mwangi, R. Lai, R. Sun, C. Long, Z. Zhang*. Purification and characterization of a novel anti-coagulant from the leech Hirudinaria manillensis.Zoological Research. 2019, 40(3): 205-210. 1区,IF:7.0

17. F. WuK. Dong, M. Zhu, Q. Zhang, B. Xie, D. Li, H.Gan, Z. Zhang* Development of a method to analyze the complexes of enoxaparin and plateletfactor 4 with size-exclusion chromatography, Jounral of Pharmaceutical and Biomedical Analysis, 2019, 164, 668-671. 3,  IF3.6

18. Y. Ouyang, X. Han, Y. Yu, J. Chen, L. Fu, F. Zhang, R. Linhardt, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta, Z. Zhang,* K. Xia*. Chemometric analysis of porcine, bovine and ovine heparins, Jounral of Pharmaceutical and Biomedical Analysis, 2019, 164, 345-352. 3,  IF3.6

19. L. Yi, Q. Zhang, Y. Meng, J. Hao, B. Xie, H. Gan, D. Li, K. Dong, Z. Zhang*  Qualitative and quantitative analysis of 2, 5-anhydro-D-mannitol in low molecular weight heparins with high performance anion exchange chromatography hyphenated quadrupole time of flight mass spectrometry, Journal of Chromatography A. 2018, 1569:160-167. 2区,IF:4.6

20. Z. Liu, Y. Xiong, L. Yi, R. Dai, Y. Wang, M. Sun, X. Xiao, Z. Zhang*, S. Yuan*, Endo-β-1,3-glucanase digestion combined with the HPAEC-PAD-MS/MS analysis reveals the structural differences between two laminarins with different bioactivities, Carbohydrate Polymers, 2018, 194, 339-349. 1,  IF:10.7

21. R. Tang1, J. Hao1, R.Zong, F. Wu, Y. Zeng, Z. Zhang*, Oxidation pattern of curdlan with TEMPO-mediated system, Carbohydrate Polymers, 2018, 186, 9-16. 1,  IF:10.7

22. Y. Ouyang, Y. Zeng, L. Yi, H. Tang, D. Li, R. Linhardt, Z. Zhang* Qualitative and quantitative analysis of heparin and low molecular weight heparins using size exclusion chromatography with multiple angle laser scattering/refractive index and inductively coupled plasma/mass spectrometry detectors, Journal of Chromatography A. 2017, 1522(3): 56-61, 2区,IF:4.6

23. L. Xu, Z. Zhang*, X. Sun, J. Wang, W. Xu, L. Shi, J. Lu, J. Tang, J. Liu, X. Su.Glycosylation status of bone sialoprotein and its role in mineralization,Experimental cell research, 2017, 17:30514-1. 2区,IF:4.1

24. Y. Rong, N Xu, B Xie, J Hao, L Yi, R Cheng, D Li, R. J. Linhardt, Z. Zhang,* Sequencing analysis of β-glucan from highland barley with high performance anion exchange chromatography coupled to quadrupole time – of – flight mass spectrometry, Food Hydrocolloids,2017, 73, 235-242. 1区,IF:11.5

25. X. Sun, L. Tao, L. Yi, Y. Ouyang, N. Xu, D. Li, R. Linhardt, Z. Zhang* N-glycans released from glycoproteins using a commercial kit andcomprehensively analyzed with a hypothetical database, Journal of Pharmaceutical Analysis, 2017, 7(2): 87-94.  1,  IF14.0

26. L. Tao, F. Song, N. Xu, D. Li, R.J. Linhardt, Z. Zhang* New Insights into the Action of Bacterial Chondroitinase AC I and Hyaluronidase on Hyaluronic Acid, Carbohydrate Polymers, 2017, 158: 85-92. 1,  IF:10.7

27. J. Hao, S. Xu, N. Xu, D. Li, R.J Linhardt, Z. Zhang*  Impact of Degree of Oxidation on the Physicochemical Properties of Microcrystalline Cellulose Carbohydrate Polymers, 2017, 155, 483-490. 1,  IF:10.7

 

已授权专利

 

1. 一种针筒式滤膜过滤器收纳盒,授权日期:2021.11.23,专利号:CN202120450809.X

2. 一种分析天平称量配件组合收纳装置,授权日期:2021.11.23,专利号:CN202120397765.9

3. 一种风琴式色谱柱收纳包,授权日期:2021.05.14,专利号:CN202021705367.0

4. 一种离子色谱-质谱联用在线检测保护装置,授权日期:2021.05.14,专利号:CN202021478056.5

5. 一种北沙参多糖及其制备方法和应用,授权日期:2021.11.02,专利号:CN202010704732.4

6. 氧化型1,4-β-D-葡萄糖醛酸寡糖在制备治疗阿尔茨海默病的药物中的应用,授权日期:2021.03.02,专利号:CN201811136880.X

7. 一种分离的防风多糖及其用途,授权日期:2022.01.18,专利号:CN201810114242.1

8. 一种分离的防风多糖及其用途,授权日期:2022.03.04,专利号:CN201810114240.2

9. 一种β-1,3-葡萄糖醛酸寡糖、及其制备方法和用途;授权日期:2022.06.21,专利号:CN202010187802.3

10. 不饱和透明质酸奇数寡糖及其制备方法,授权日期:2019.05.03,专利号:CN201611020047.X

11. 一种氧化型α‑1,4‑寡聚葡萄糖醛酸及其制备方法和用途,授权日期:2021.03.16,专利号:CN201680029752.8

12. 一种氧化型β-1,4-寡聚葡萄糖醛酸及其制备方法和用途,授权日期:2018.06.19,专利号:CN201510267009.3

13. 一种氧化型α-1,4-寡聚葡萄糖醛酸及其制备方法和用途,授权日期:2018.08.24,专利号:CN201510267211.6

 

李笃信 博士

:副教授 

联系邮箱duxin.li@suda.edu.cn 

联系地址:苏州大学独墅湖校区南区云轩楼1131 

 

 

研究方向

1. 二维液相色谱质谱(LC x LC – QTOF/MS)新方法新技术开发;

2. 天然产物提取分析及其在药品、食品和化妆品中的应用开发; 

3. 基于肠道菌群的代谢组学和药代动力学研究;

 

  

主持或参与的课题

1. 61批国家博士后项目,7131701117,基于二维液相质谱的骨唾液酸蛋白质糖组学研究,2018/01-2019/12,主持。

2. 国家自然科学基金面上项目,81673388,肝素类药物的糖组学研究,2017/01-2020/12,参与。

3. 江苏省科学技术厅重点研发计划(社会发展),高值栀子黄及其副产物综合加工关键技术研究及产品开发,2019/01–2021/12, 参与。

4. 苏州市重点产业技术创新,豆制品加工过程废弃物的资源化利用关键技术研发及产业化,2019/06-2021/06, 子课题负责人。

5. 企业课题,siRNA/DNA序列确证方法学研究,2017.01 - 2022.12,主持。

6. 企业课题,一种中药单体药效作用机理研究,2021.07 – 2022.12,主持。

7. 企业课题,制备型二维液相色谱系统开发,2019.04-2022.03,主持。

8. 企业课题,卡拉胶及其代谢物生物安全性评估,2020.05-2021.12,主持。

9. 企业课题,白葛根醪糟创新产品开发,2020.09-2023.09,主持;

 

代表性论文 

 

1. Yan N, Li X, Zhou CD, Jiang Q, Li JY, Zhang Z, Ouyang YL*, Li DX*, Li JX* (2022) Characterization of degradation products of carrageenan by LC-QTOF/MS with a hypothetical database. Food Chem 384:132504.

2. Li DX*, Qi ZY, Liu JY, Zhou JQ (2022) Effect of pH on the conformational structure of cytochrome c and subsequent enzymatic cross-linking catalyzed by laccase. Electronic Journal of Biotechnology. 2022, 60, 1-10.

3. Ain NU, Wu SY, Li X, Li DX*, Zhang ZQ* (2022) Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review. Materials 15 (10):3654

4. Lan T, Yan N, Pei D, Liu J, Yu C, Chu Q, Li DX* (2021) Determination of Five Carotenoids in Eggs and Chicken by HPLC. Science and Technology of Food Industry, 2021, 42(20): 261−267. (in Chinese with English abstract).

5. Xu S, Li Z, Zhang LY, Zhang WB, Li DX* (2021) In situ growth of COF-rLZU1 on the surface of silica sphere as stationary phase for high performance liquid chromatography. Talanta 221:121612.

6. Zhu M, Li DX*, Yang KG, Li FC, Zhang ZQ (2020) Degradation characteristics of enoxaparin sodium by heparinase I from various sources. Chinese Journal of Pharmaceutcial Analysis. 40 (07):1254-1261. (in Chinese with English abstract).

7. Chu ZY, Zhang WB, Li DX*, Zhang LY, Zhu MM, Ge ZS (2020) Synthesis and chromatographic evaluation of poly(pentabromostyrene)-silica composite: A versatile stationary phase for separating both polar and non-polar aromatic compounds. Microchem J 156:104838. doi:ARTN 104838

8. Niu X, Yan N, Li DX, Ma WP, Shi Y, Liu JY, Zhou S (2019) Separation and in vitro gut metabolism analysis of polysaccharides from the fruits of Lycium Barbarum. Natural Product Research and Development. 31 (10):1682-1687+1730.

9. Wu F, Dong K, Zhu M, Zhang Q, Xie B, Li DX, Gan H, Linhardt RJ, Zhang ZQ (2019) Development of a method to analyze the complexes of enoxaparin and platelet factor 4 with size-exclusion chromatography. J Pharm Biomed Anal 164:668-671.

10. Meng Y, Yi L, Chen L, Hao J, Li DX, Xue J, Xu NY, Zhang ZQ (2019) Purification, structure characterization and antioxidant activity of polysaccharides from Saposhnikovia divaricata. Chin J Nat Med 17 (10):792-800.

11. Yi L, Zhang Q, Meng Y, Hao J, Xie B, Gan H, Li DX, Dong K, Zhang Z (2018) Qualitative and quantitative analysis of 2, 5-anhydro-d-mannitol in low molecular weight heparins with high performance anion exchange chromatography hyphenated quadrupole time of flight mass spectrometry. J Chromatogr A 1569:160-167.

12. Tao L, Song F, Xu N, Li DX, Linhardt RJ, Zhang Z (2017) New insights into the action of bacterial chondroitinase AC I and hyaluronidase on hyaluronic acid. Carbohydr Polym 158:85-92.

13. Sun X, Tao L, Yi L, Ouyang Y, Xu N, Li DX, Linhardt RJ, Zhang Z (2017) N-glycans released from glycoproteins using a commercial kit and comprehensively analyzed with a hypothetical database. J Pharm Anal 7 (2):87-94.

14. Ouyang Y, Zeng Y, Yi L, Tang H, Li DX, Linhardt RJ, Zhang Z (2017) Qualitative and quantitative analysis of heparin and low molecular weight heparins using size exclusion chromatography with multiple angle laser scattering/refractive index and inductively coupled plasma/mass spectrometry detectors. J Chromatogr A 1522:56-61.

15. Hao J, Xu S, Xu N, Li DX, Linhardt RJ, Zhang Z (2017) Impact of degree of oxidation on the physicochemical properties of microcrystalline cellulose. Carbohydr Polym 155:483-490.

 

授权发明专利 

1. 李笃信,唐红,张真庆.  一种高温全二维液相色谱装置及其使用方法, 2017-1-15, 中国, ZL 201710060507.X.

2. 李笃信,易琳,朱梦,张真庆,邱飘飘,闫娜. 一种三维液相色谱蛋白纯化装置及其使用方法, 2018-9-28, 中国, ZL201811137039.2

3. 李笃信,杨凯歌,陈喜华,闫娜,唐红,张真庆. 一种液相色谱馏分收集器及使用方法, 2018-1-23, 中国, ZL2018110065496.9

4. 李笃信,易琳,孙瑞琪,陆菲菲,张真庆. 一种离心超滤样品处理装置及其使用方法, 2021-1-8, 中国, ZL201811136896.0

5. 李笃信,兰韬,高叶,刘嘉雯,邱飘飘. 一种双溶剂结合中压液相色谱分离纯化高纯度斑蝥黄的方法,2021-05-04,中国,ZL201910481317.4

6. 李笃信 , 赵磊 , 张健 , 刘江云 , 朱雪雪 , 张明锦. 一种香豆素类化合物在制备治疗乙肝药物中的应用. 2022-03-29,中国,ZL202010777651.7. 


 

 


徐乃玉苏州大学药学院副教授(xunaiyu@suda.edu.cn

徐乃玉副教授于1997年获得沈阳药科大学药学学士学位,随后进入苏州大学任职,并于2003年、2008年取得苏州大学硕士、博士学位。主要研究方向是天然产物成分分析及其药效学评价。

近五年承担的科研项目

1. 国家自然科学基金面上项目,81673388,肝素类药物的糖组学研究,2017/01-2020/12,参与。

2. 国家自然科学基金面上项目,81473179,复杂蛋白聚糖的序列分析,2015/01-2018/12,参与。

3. 江苏省自然基金面上项目,SBK201122569,野马追保护急性肺损伤的活性成分及作用机制研究2011/07-2014/07,参与。

近五年发表论文

1. N. Xu, C. Chu, L. Xia, J. Zhang, D. Chen*, Protective effects of Rabdosia japonica var. glaucocalyx extract on lipopolysaccharide-induced acute lung injury in mice, Chinese Journal of Natural Medicines, 2015, 10, 767-775.

2. Q. Sun, N. Xu, Q. Li, S. Yao, M. Li, H. Li, J. Zhang, D. Chen*, Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DC. Journal of Functional Foods, 2017, 38, 321–328.

3. L. Tao, F. Song, N. Xu, D. Li, R.J. Linhardt, Z. Zhang*, New insights into the action of bacterial chondroitinase AC I and hyaluronidase on hyaluronic acid, Carbohydrate polymers, 2017, 158, 85-92.


 


欧阳艺兰苏州大学药学院讲师(y_ouyang@suda.edu.cn),苏州大学优秀青年学者,分别于2013年、2016年、2019年获得黑龙江大学制药工程工学学士学位、苏州大学药物分析硕士和博士学位。2017-2018年赴美伦斯勒理工学院联合培养。主要研究方向是肝素类药物的结构分析与糖类药物的研究与开发。2020年荣获江苏省“双创博士”。

近五年承担的科研项目

1. 国家自然科学基金青年项目(82003708),基于毛细管电泳质谱联用技术(CE-MS)的非抗凝肝素序列解析及其抗炎构效关系研究,2021.01-2023.12,主持。

2. 国家自然科学基金面上项目81673388),肝素类药物糖组学研究,2017.01-2020.12,参与。

3. 国家自然科学基金面上项目(81473179,复杂蛋白聚糖的序列分析,2015.01-2018.12,参与。

近五年代表论文

1. N. Yan, X. Li, C. Zhou, Q. Jiang, J. Li, Z. Zhang, Y. Ouyang*, D. Li*, J. Li*; Characterization of degradation products of carrageenan by LC-QTOFMS with a hypothetical database, Food Chemistry, 2022, 384: 132504.2,  IF:7.5

2. L. Chen; Y. Ouyang; N. Yan; Y. Guo; L. Yi; Y. Sun; D. Liu; Z. Zhang*; Comprehensive analysis of heparinase derived heparin-products using two-dimensional liquid chromatography coupled with mass spectrometry, Journal of Chromatography A, 2021, 1643: 462042-462049. 2,  IF:4.6

3. L. Chen, W. Zhu, N. Yan, Y. Guo, L. Yi, Y. Ouyang*, Z. Zhang*; Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS, Journal of Pharmaceutical and Biomedical Analysis, 2022, 212:114616-114323. 3,  IF:3.6

4. Y. Ouyang, M. Zhu, X.Wang, L. Yi, Y. Yao, J. Fareed, R. J Linhardt*, Z. Zhang,* Systematic analysis of enoxaparins from different sources with online one and two-dimensional chromatography, Analyst. 2019, 144, 3746-3755.2区,IF:5.2

5. Y. Ouyang, Y. Yu, F. Zhang, J. Chen, X. Han, K. Xia, Y.Yao, Z. Zhang,* R.J. Linhardt*, Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications, Journal Medicinal Chemistry, 2019, 62, 1067-1073.2区,IF:8.0.

6. Y. Ouyang, X. Han, Q. Xia, J. Chen, S. Velagapudi, K. Xia,Z. Zhang* and R.J Linhardt* Negative-ion Mode Capillary Isoelectric Focusing-Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides, Analytical Chemistry, 2019, 91, 846-853.  1,  IF:8.0

7. Y. Ouyang, X. Han, Y. Yu, J. Chen, L. Fu, F. Zhang, R. Linhardt, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta, Z. Zhang,* K. Xia*. Chemometric analysis of porcine, bovine and ovine heparins, Jounral of Pharmaceutical and Biomedical Analysis, 2019, 164, 345-352. 3,  IF:3.6

8. Y. Ouyang, Y. Zeng, L. Yi, H. Tang, D. Li, R. Linhardt, Z. Zhang* Qualitative and quantitative analysis of heparin and low molecular weight heparins using size exclusion chromatography with multiple angle laser scattering/refractive index and inductively coupled plasma/mass spectrometry detectors, Journal of Chromatography A. 2017, 1522(3): 56-61. 2,  IF:4.6




姓名:易琳

职务职称:助理研究员、硕士生导师

电子邮箱:yilin@suda.edu.cn

办公地址:云轩楼1134

教育经历

2017-09  2020-06苏州大学,药物分析学,博士

2014-092016-06,苏州大学,药学,硕士

2010-092014-06苏州大学,药学,学士

研究经历

2018.11-2020.06,Eshelman School of Pharmacy University of North Carolina at Chapel Hill,访问学者

2020.09-至今,苏州大学药学院,助理研究员

研究方向

1.肝素类糖胺聚糖质量控制新方法研究

2. 基于离子色谱(HPAEC-PAD)与飞行时间质谱(Q-TOF)联用技术精准解析多糖结构序列的研究

3. 不同来源β葡聚糖结构序列解析与免疫调节生物活性的构效关系研究

4. 化学生物酶法合成结构均一的肝素寡糖研究

5. 多糖铁剂、多糖纳米载体材料研究

科研项目

1. 国家自然科学基金委员会,青年项目,82204331,基于HPAEC-PAD-MS/MS联用方法的β-葡聚糖序列结构解析及其构效关系研究新策略, 20231 202512月,30万元,在研,主持

2. 江苏省委组织部等12个单位,人才项目,JSSCBS20210701,江苏省双创博士 2021-09  2023-09, 15万元,在研,主持

3. 湖北亿诺瑞生物制药有限公司, 民口横向, H211770依诺肝素钠序列分析及与PF4相互作用研究, 202 1-12  2023-06100万元,在研,主持

4. 国家自然科学基金委员会,面上项目,81673388肝素类药物的糖组学研究, 2017101  202012月,51万,结题,重要参与者

5. 国家自然科学基金委员会,面上项目, 81473179,复杂蛋白聚糖的序列分析, 20151月至201812月,80万,结题,重要参与者

代表性研究成果

1. Na Yan, Feifan Song, Yilan Ouyang, Duxin Li, He Tian, Lin Yi*, Robert J. Linhardt; Zhenqing Zhang*; Glycan Mapping of Low-Molecular-Weight Heparin Using Mass Spectral Correction Based on Chromatography Fitting with“Glycomapping” Software, analytical chemistry, 2022, 94:13000-13009(共同通讯作者)1区,IF:8.0

2. Bingying Xie1; Lin Yi1; Yiting Zhu; Xiaoming Chang; Jie Hao; Li Pang; Yilan Ouyang; Sheng Yuan; Zhenqing Zhang ; Structural elucidation of a branch-on-branch β-glucan from Hericium erinac euswith A HPAEC-PAD-MS system,CarbohydratePolymers, 2021, 251: 117080-117091 (共同第一作者)1区,  IF:10.7

3. Lin Yi; Yongmei Xu; Andrea M. Kaminski; Xiaobing Chang; Vijayakanth Pagadala; Maurice Hor ton; Guowei Su; Zhangjie Wang; Genmin Lu; Pamela Conley; Zhenqing Zhang; Lars C. Pedersen; Jian L iu ; Using engineered 6-O-sulfotransferase to improve the synthesis of anticoagulant heparin, OrganicandBiomolecularChemistry, 2020,18:8094-8102.3区, IF:3.9

4. Lin Yi; Qinghua Zhang; Yao Meng; Jie Hao; Bingying Xie; Hao Gan; Duxin Li; Kai Dong; Zhen qing Zhang ; Qualitative and quantitative analysis of 2,5-anhydro-D-mannitol in low molecular wei ght heparins with high performance anion exchange chromatography hyphenated quadrupole time of fl ightmassspectrometry,JournalofChromatographyA, 2018,1569:160-167.2区,IF:4.6

5. Lin Yi; Yilan Ouyang; Xue Sun; Naiyu Xu; Robert J Linhardt; Zhenqing Zhang ; Qualitative and quantitative analysis of branches in dextran using high-performance anion exchange chromatogr aphy coupled to quadrupole time-of-flight mass spectrometry, Journal of Chromatography A, 2015,1 423:79-85. 2区,IF:4.6

6. Lin Yi; Xue Sun; Kenze Du; Yilan Ouyang; Chengling Wu; Naiyu Xu; Robert J Linhardt; Zhenqing Zhang ; UP-HILIC-MS/MS to determine the action pattern of Penicillium sp. Dextranase, Journal of the American Society for Mass Spectrometry, 2015, 26: 1174-1185. 3区, IF:3.3

专利

1. 张真庆,郝杰,易琳,郁倩文。一种β-1,3-葡萄糖醛酸寡糖、及其制备方法和用途,授权日期:2021.06.21,专利号:CN202010187802.3

2. 李笃信,易琳,孙瑞琪,陆菲菲,张真庆。一种离心超滤样品处理装置及其使用方法,授权日期:2021.03.02专利号:CN109406252B

3. 李笃信,易琳,朱梦,张真庆,邱飘飘,闫娜。一种三维液相色谱蛋白纯化装置及其使用方法授权日期:2020.06.09,专利号:CN109030686B

4. 李笃信,闫娜,朱雪雪,苏佳佳,朱梦,易琳,张真庆。一种蛋白糖基化分析装置,授权日期:2018.10.19,专利号:CN207992131U

5.李笃信邱飘飘易琳朱雪雪闫娜张真庆 一种加压型快速透析装置,授权日期:2019.08.27,专利号:CN209301846U

6.张真庆 吴芳霞李笃信易琳欧阳艺兰 β-1,4型葡萄糖醛酸/甘露糖醛酸直链杂合寡糖及其制备方法和应用。申请日期:2021.08.31,申请号202111010709.6(审中)

7.张真庆,易琳,赵婧雯,田禾,郑捷,卢文博,魏羽瑶。一种速率反应装置、方法及其在发色底物法上的应用。申请日期:2022.04.28,申请号:CN202210460775.1(审中)

8. 张真庆,陈磊,欧阳艺兰,易琳李笃信。一种用于低分子量肝素质量分析的二维液相-质谱联用方法,申请日期:2022.04.08,申请号:CN202210365757.5(审中)

9.张真庆,陈磊,欧阳艺兰,易琳李笃信。一种部分抗凝肝素衍生物及其制备方法和应用,申请日期:2022.02.25,申请号:CN202210176221.9(审中)

10. 张真庆,闫娜,李笃信,宋非凡,欧阳艺兰,易琳 一种色谱质谱分析用数据处理方法,申请日期:2022.01.06,申请号:CN202210008618.7(审中)