Gating of Potassium Channels by Calcium

报告题目:  Gating of Potassium Channels by Calcium
报 告 人：Richard Warren Aldrich, PhD, Professor
报告时间：2011年7月28日（星期四）下午3:00
报告地点：独墅湖校区炳麟图书馆712 会议室

报告人简介：
Prof. Richard Aldrich graduated with high distinction from the University of Arizona in 1975 with a Bachelor of Sciences degree in Biological Sciences. He received his Ph.D. in Neuroscience from Stanford University in 1980, after which he did postdoctoral work at Yale University in Physiology. He joined the faculty at Yale in the Section of Molecular Neurobiology before returning to Stanford in 1985 as a faculty member in the Department of Neurobiology and subsequently the Department of Molecular and Cellular Physiology, where he served as department chair from 2001-2004. Dr. Aldrich was a member of the Howard Hughes Medical Institute from 1990 until moving to The University of Texas in 2006, where he is Professor and Chair of the Section of Neurobiology in the School of Biological Sciences and the Karl Folkers Chair II in Interdisciplinary Biomedical Research. He has served on the council and as president of the Society of General Physiologists, as a Fellow of the Biophysical Society and a member of editorial board of some journals such as BioMed Central Neuroscience, PLoS Biology, PLoSONE, Channels and Proceedings of the National Academy of Sciences U.S.A.

PUBLICATIONS (2006-2011)
1. Misonou, H., Menegola, M., Buchwalder, L., Park, E. W., Meredith, A., Rhodes, K. J., Aldrich, R. W., and Trimmer, J. S.    2006.  Immunolocalization of the Ca2+-activated K channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons.  Journal of Comparative Neurology. 496:289-302.

2.Piskorowski, R. A., and Aldrich, R. W. 2006. Relationship between pore occupancy and gating in BK potassium channels.  Journal of General Physiology. 127:557-576.

3.Fodor, A. and Aldrich, R. W.  2006. Statistical limits to the identification of ion channel domains by sequence similarity. Journal of General Physiology. 127:755-766.

4.Sack, J. and Aldrich, R. W.  2006.  Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel’s activation pathway. Journal of General Physiology. 128:119-132.

5.Meredith, A. L., Wiler, S. W., Miller, B. H., Takahashi, J. S., Fodor, A. A. Ruby N. F., and Aldrich, R. W. 2006.  BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nature Neuroscience. 9:1042-1049.

6.Wilkins, C. M., and Aldrich, R. W.  2006.  State independent block of BK channels by an intracellular quaternary ammonium.  Journal of General Physiology. 128:347-364.

7.Li, W. and Aldrich R. W.  2006.  State dependent block of BK channels by synthesized Shaker ball peptides.  Journal of General Physiology. 128:423-441.

8.Filosa, J. A., Bonev, A. D., Straub, S. V., Meredith, A. L., Aldrich, R. W. and Nelson, M. T.  2006.  Local potassium signaling couples neuronal activity to vasodilation in the brain.  Nature Neuroscience. 9:1397-1403.

9.Werner, M. E., Knorn, A., Meredith A. L., Aldrich, R. W. and Nelson, M. T.  2007. Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: Modulation by BK channels.  American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 292:616-624. (published online September 24, 2006)

10. Pyott, S. J., Meredith, A. L., Fodor, A. F., Vazquez, A. E., Yamoah, E. N. and Aldrich, R. W.  2007.  Cochlear function in mice lacking the BK channel a, b1, or b4 subunits.  Journal of Biological Chemistry.  282:3313-3324.  (published on line November 29, 2006)

11.Werner, M. E., Meredith, A. L., Aldrich R. W. and Nelson, M. T.  2008.  Hyper-contractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction.  American Journal of Physiology. 295:R181-R188.

12.Yan, J, Olsen, J. V., Park, K-S, Li, W., Bildl, W., Schulte, Aldrich, R. W., Fakler, B. and Trimmer, J. S. 2008.  Profiling the phospho-status of the BKca channel a subunit in rat brain reveals unexpected patterns and complexity.  Molecular and Cellular Proteomics. 7:2188-2198. (published on line June 23, 2008)

13.Brown, S. M., Bentcheva-Petkova, L. M., Liu, L., Hristov, K. L., Chen, M., Kellet, W. F., Meredith, A. M., Aldrich, R. W., Nelson, M. T., and Petkov, G. V.   2008.  Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large conductance Ca2+-activated K+ channel.  American Journal of Physiology (published on line August 13, 2008)

14.Imlach, W. L., Finch, S. C., Dunlap, J., Meredith, A. L., Aldrich, R. W., and Dalziel, J. E.  2008.  The molecular mechanism of “Ryegrass staggers” a neurological disorder of potassium channels.  Journal of Pharmacology and Experimental Therapeutics. 327:657-664. (published on line September 18, 2008)

15.Fodor, A. A. and Aldrich, R. W.  2009.  Convergent evolution of alternative splices at domain boundaries of the BK channel.  Annual Review of Physiology. 71:19-36. (published on line August 2008)

16.Li, W. and Aldrich, R. W.  2009. Activation of the SK Potassium Channel-Calmodulin Complex by Nanomolar Concentrations of Terbium.  PNAS. 106:1075-1080.

17.Li, W., Halling, D.B., Hall, A.H. and Aldrich, R. W.  2009.  EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK-calmodulin interaction. Journal of General Physiology 134:281-293. (published on line September 14, 2009).

18.Girouard, H., Bonev, A.D., Hannah, R.M., Meredith, A. M., Aldrich, R. W., and Nelson, M. T. 2010.  Astroycytic endfoot Ca²⁺ and BK channels determine bother arteriolar dilation and constriction.  PNAS. 107:3811-3816.

19.Yan, J., and Aldrich, R.W. 2010; An auxiliary LRRC26 protein allows BK channel activation at resting voltage without calcium  Nature 466:513-517 (doi:10.1038/nature09162).

20.Li, W., and Aldrich, R.W.  2011;  Electrostatic influences of charged inner pore residues on the conductance and gating of SK potassium channels. PNAS. Published online

21.Liu, H., and Aldrich, R.W. 2011; Tissue-specific N-terminus of hyperpolarization-activated cyclic nucleotide-gated (HCN) 4 channel affects channel activation. J. Biol. Chem. Published online