Ming Chen, Ph.D. hosted by Prof. Samir Mitragotri
Department of Chemical engineering, UCSB
报告时间：2014年2月19日（星期三）14:00
报告地点：独墅湖校区二期云轩楼2301室
报告摘要
Skin is the largest organ of the human body, which covers a surface area between 1.5~ 2.0 m2. From a pharmaceutical point of view, skin offers an outstanding route for therapeutic delivery with several advantages over other means of administration.The range of drugs delivered through the skin, either for systemic or for local applications, however, has been very narrow owing to skin’s barrier properties characterized by low permeability which restricts the use of transdermal delivery to hydrophobic drugs with molecular weights less than 500Da. However, an increasing number of biopharmaceuticals and macromolecules are being developed for therapeutic, medical and personal care applications, which are difficult to deliver by conventional means. Skin penetrating peptides offer a potential means to enhance dermal/transdermal delivery of macromolecules. SPACE-Peptide was discovered through phage display and was shown to deliver siRNA and streptavidin into skin after direct chemical conjugation. While chemical conjugation of SPACE peptide with the cargo demonstrates feasibility of the approach, the conjugation process also poses certain hurdles. Specifically, the conjugation process requires chemical modification of the cargo which could alter its chemical, biological and pharmaceutical properties. In addition, conjugation may not be feasible for certain drugs, thus limiting the applicability of the peptide as an enhancer. Therefore, we use SPACE-peptide as a part of a lipid-based carrier system encapsulating and delivering macromolecular cargoes into skin without chemical conjugation.
报告人简介
陈铭，男，1979 年生，博士。2002 年毕业于北京大学药学院获理学学士学位，2007 年毕业于北京大学药学院获理学硕士学位。2011 年毕业于德国耶拿大学获药剂学博士学位。2011 年至今在加州大学圣芭芭拉分校化学工程系从事博士后研究工作。在博士和博士后期间，与Biolitec AG，Convoy Therapeutics, Inc.等制药公司有合作项目，从事产品的研发和商业化工作。主要研究方向是经皮给药系统，脂质体给药系统和多肽促渗剂给药系统。目前已在国际药剂学主流刊物Journal of Controlled Release 、International journal of Pharmaceutic ， Journal of Biomedical Nanotechnology 等发表SCI 论文10 余篇，并申请了一项国际专利。
