[4-14]Caspase-sensitive molecular probes for multimodality imaging tumor cell death

报告题目：Caspase-sensitive molecular probes for multimodality imaging tumor cell death

报 告 人：叶德举 博士（美国斯坦福大学医学院博士后）

报告时间：2014年4月14日（星期一）下午2:00

报告地点：独墅湖校区二期云轩楼2301室

报告摘要：
Caspase proteins are a family of cysteine proteases that play essential roles in apoptosis by initiating, regulating, and executing downstream proteolytic events during programmed cell death. It has been recognized that radio- and chemotherapy-induced tumor cell death often leads to the activation of caspase-3/7, an “executioner” for cell apoptosis.31,32 Therefore, caspase-3/7 has become an important early biomarker for evaluating apoptosis-promoting antitumor therapies, imaging of which can provide invaluable predictive information regarding therapeutic efficacy and anti-cancer drug selection. Herein, I will present the development of caspase-responsive multimodality imaging probes, including fluorescence, MRI, and PET probes, and their applications for non-invasive monitoring of tumor therapy response in living mice.