报告题目：Induction of paraptosis by chalcomoracin through PINK1-mediated mitophagy in cancer cells
报 告 人：刘江云 副教授（苏州大学药学院天然药物化学教研室）
报告时间：2015年3月30日(周一)下午2:00pm
报告地点：云轩楼1323室
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Abstract:
Natural Products kept promising compound libraries for searching new anti-cancer agents. In this study, about 40 compounds were screened for their potential anti-tumor activities, and S5 (chalcomoracin, isolated from mulberry) showed strong cytotoxities (IC50mM) on several cell lines in vitro, including MDA-MB-231, PC-3, and HCT-116 tumor cells. Moreover, it induced cell death by characteristic paraptosis pathway. Molecular mechanisms of S5 were further investigated, and PINK-1 was proved to induce mitophagy , which influenced sequential downstream signals including Alix, GRP78, Chop etc., and resulted in endoplasmic reticulum stress, multivesicular bodies and final paraptosis and cell death. Detailed molecular pathway of paraptosis indused by S5 are now under further investigation. 5-8
