报告题目：Chemical Strategy to Construct Fe2+/H2O2 Signaling Pathways based on the Chemically Induced Proximity (CIP) method
报 告 人：李环球 副教授（苏州大学药学院药物化学教研室）
报告时间：2015年 4月28日（星期二）上午10：00
报告地点：独墅湖校区二期云轩楼2301室
Abstract
A new chemical strategy has been developed to generate novel signaling pathways that link signaling molecules, Fe2+/H2O2, to different downstream cellular events in mammalian cells. This approach combines the reactivity-based Fe2+/H2O2 sensing with the chemically induced protein proximity method. By chemically modifying abscisic acid (ABA) to Fe2+/H2O2-sensitive inducers, novel Fe2+/H2O2 signaling pathways can be engineered to induce transcription, protein translocation and membrane ruffle formation upon exogenous or endogenous Fe2+/H2O2 stimulation, which provides the potential to build and hold great promise for novel therapeutic applications.
