报告题目：Chromatographic and mass spectral analysis of pharmaceuticals
报告人：李笃信 博士（Universität Duisburg-Essen）
报告时间：2015年 7月6日（星期一）9：30 AM
报告地点：独墅湖校区二期云轩楼2301室
Abstract
Pharmaceutical Analysis determines the quality of drug products via analytical chemistry. High Performance Liquid Chromatography (HPLC) is the most important analytical technique used during the various stages of drug development and manufacturing . Traditional HPLC uses a single column, and this is not sufficient for analysis of samples with large numbers of chemical groups and compounds. If the number of components exceeds 37% of the peak capacity, peak resolution is statistically reduced. And if several ingredients of a sample are eluted and ionized at the same time in the ion source, then different radical cations are formed. These radical cations can react or interact with each other, leading to ion suppression and/or formation of artefacts. Therefore, a high-performance chromatographic platform in front of the MS is always the gold standard. In determination of the chemical signature (also called “fingerprint”) of complex samples, conventional one-dimensional methods do not offer sufficient selectivity and separation efficiency. A reasonable alternative is to develop multi-dimensional separation systems 。
