[3-3]NMDARs determine the balance of excitation and inhibition

报告题目：NMDARs determine the balance of excitation and inhibition
报 告 人：周亮 博士（National Institute of Neurological Disorders and Stroke，National Institutes of Health博士后）
报告时间：2016年3月3日（星期四）下午2:00
报告地点：独墅湖校区二期云轩楼2301室

报告摘要:
The imbalance of excitation and inhibition has been the most important cellular theory hypothesis of severe neuropsychiatric disease, such as autism and schizophrenia. But the mechanisms underlying balance of excitation and inhibition are largely unknown. Here, I found that NMDARs determine the balance of excitatory and inhibitory. I found that NMDARs can coordinate the development of AMPAR- and GABAAR-mediated synaptic transmission by using a single-cell genetic approach , and one single C0 domain of GluN1 subunit is required and sufficient for NMDARs to regulate AMPAR- and GABAAR-mediated synaptic transmission. At last, I will address the functions of Ng in NMDAR-mediated synaptic transmission by using electrophysiological, imaging, biochemical, and CRISPR-Cas9 techniques.

报告人简介：
I obtained my Bachelor in biology from Inner Mongolia University (IMU) in 2008, and then I joined Professor Guanghui Wang’s lab in University of Science and Technology of China (USTC) to study neurodegenerative diseases. I received my Doctorate in 2013 from USTC. After graduating, I moved to NIH for the postdoctoral training. I have worked in diverse aspects of cell biology and electrophysiology, from interactions between proteins to communications between neurons.