[6-24]Nanoparticle Based Photodynamic Therapy and Photothermal Therapy

报告题目: Nanoparticle Based Photodynamic Therapy and Photothermal Therapy
报 告 人：陈伟（Wei Chen），博士，教授
(Center for Security Advances Via Nanotechnology, University of Texas at Arlington, UTA)
报告时间：2016年06月24日（周五）下午3:30
报告地点：独墅湖校区药学院云轩楼2301学术报告室

报告摘要：
Cancer is a class of diseases in which a group of cells display uncontrolled growth. Every year, about 562,340 Americans are expected to die of cancer, more than 1,500 people a day. Cancer is the second most common cause of death in the US, exceeded only by heart disease. In the US, cancer accounts for nearly 1 of every 4 deaths. Early detection and effective treatment are the best hope for cancer patients. Photodynamic therapy (PDT) is a promising recipe for cancer treatment. However, the difficulty of light penetration into deep tissue has hitherto prevented the application of photodynamic therapy for deep cancer treatment. The three components that are required for PDT are oxygen, photosensitizers, and light. To solve the problem of light penetration and to enhance the PDT treatment for deep cancers, I have proposed a new PDT system in which the light is provided by afterglow nanoparticles with attached photosensitizers. When the nanoparticle-photosensitizer conjugates are targeted to tumor and stimulated by X-ray during radiotherapy, the particles will generate light to activate the photosensitizers for photodynamic therapy. Therefore, the radiation and photodynamic therapies are combined and occur simultaneously, and the tumor destruction will be more efficient. More importantly, it can be used for deep tumor treatment as X-ray can penetrate deep into the tissue such as Breast and prostate cancers. This novel modality is called nanoparticle self-lighting photodynamic therapy (NSLPDT). In this presentation, I will report the progress of the research in my group on the design, synthesis and evaluation of nanoparticle conjugates for photodynamic therapy.

Along with PDT, PTT (Photothermal Therapy) is also an effective method for cancer treatment. In our innovative studies, we investigated the potential of CuS nanoparticles for PTT. CuS nanoparticles have optical absorption band in the NIR range with a maximum at 900 nm. Irradiation by a NIR laser beam at 808 nm, the temperature in CuS nanoparticle aqueous solution is increased as a function of exposure time and nanoparticle concentration. CuS nanoparticles induced photothermal destruction of HeLa cells in a laser dose- and nanoparticle concentration-dependent manner, and displayed minimal cytotoxic effects with a profile similar to that of gold nanoparticles.   Owing to their unique optical property, small size, low cost of production, and low cytotoxicity, CuS nanoparticles are promising new nanomaterials for cancer photothermal ablation therapy.

In the last part of my presentation, I will briefly introduce my work on drug delivery and targeting and my research projects on radiation detection for homeland security.

报告人简介：
陈伟（Wei Chen）博士，德克萨斯大学（The University of Texas at Arlington, UTA）物理系纳米生物物理专业终身教授、UTA纳米技术联合安全研究中心（the Center for Security Advances Via Nanotechnology）主任。
陈伟本科毕业于吉林大学地球科学院，硕士毕业于中南大学地球与物理学院，博士毕业于北京大学化学学院。1992.3-1994.6中国科技大学材料物理系博士后；1994.6-1998.8中国科学院重点实验室—半导体材料科学重点实验室，任实验室副主任、研究员。1998.8- 1999.5瑞典隆德大学材料化学系（Department of Materials Chemistry, Lund University, Sweden），博士后；1999.6-2000.3任加拿大西安大略大学化学物理中心（Chemical Physical Center, University of Western Ontario, Canada）高级研究员。2000年至2006年，任职于Nomadics公司（现Flir系统公司），纳米技术研究组组长。2006年至今，UTA物理系助理教授 （2006-2010），副教授（2011-2012）、正教授 （2013 – present），UTA纳米技术联合安全研究中心（the Center for Security Advances Via Nanotechnology）主任。
多年来一直从事纳米技术的尖端研究，系国际著名纳米药物和癌症纳米技术专家。率先提出纳米颗粒自发光光动力学治疗癌症的概念，利用纳米颗粒使得放射治疗和光动力学治疗同时进行，有望用于深部癌症治疗。在纳米颗粒的热释发光和光激励发光（PSL）及其在放射治疗中的应用研究上一直处于世界领先地位。第一个证明了纳米材料可以作为癌症诊断和治疗的工具，并引起纳米技术行业的关注，获得了国际学术界极高评价。最近，与合作者首次研究了CuS纳米颗粒作为治疗癌症的光热加热剂，效果明显优于目前热门的Au纳米颗粒，且经济便宜100倍；该技术已获得了专利。
作为项目负责人，曾获得20项、共计约900万美元创新研究基金。在国际重要刊物上已发表SCI论文200多篇，论文被引用超过7000次，他有19篇论文被引用超过100次，其中一篇论文就被引用超过600次， 目前他的H影响因子为41。 Charles P. Poole Jr.与Frank J. Owens在2003 所著的美国第一本纳米技术教科书《纳米技术介绍》中介绍了他的开创性工作和重要贡献。主编或参编出版国外专著14部，获得专利10项，待批专利10项。提出通过设计、制备纳米结构磷光体，利用金属纳米颗粒表面等离子体基元的局域场增强效应来提高辐射检测所用纳米颗粒闪烁体的发光效率。与Agiltron公司合作，设计、合成用于辐射检测的纳米复合材料。在UTA组建国土安全研究中心，依托在纳米颗粒和检测上的强项来处理各种安全问题。与弗吉尼亚的高科技公司（Luna创新公司）开展了用于生物传感器的近红外（NIR）纳米颗粒的合作研究，设计和合成的纳米复合材料不仅在癌症治疗上有巨大的潜力，而且在关乎人类健康和安全的生物试剂防护和检测方面也具有巨大应用前景。
曾获中科院杰出青年科学家奖、中国教育部和北京大学学术奖及德州大学科技成果奖。现担任生物医学纳米技术杂志（Journal of Biomedical Nanotechnology IF 7.8）副主编，Journal of Nanoscience and Nanotechnology北美主编，纳米科学与技术评论杂志（Reviews in Nanoscience and Nanotechnology）主编。
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