[10-26] RNA纳米颗粒作为新一代药物



报 告 人:Peixuan Guo (郭培宣), Ph.D., Professor 

     First Sylvan G. Frank Endowed Chair in Pharmaceutics and Drug Delivery Systems

     Director of NCI Cancer Nanotechnology Platform Partnership Program in RNA Nanotechnology for Cancer Therapy

    College of Pharmacy

  The Ohio State University 






Dr. Peixuan Guo received his Ph.D. in Microbiology and Genetics with training in biophysics from the University of Minnesota in 1987. He was a postdoc at NIH before joining Purdue University as an assistant professor in 1990, tenured in 1993, full Professor in 1997, and was honored as a Purdue Faculty Scholar in 1998. He was recruited to University of Cincinnati as the Dane & Mary Louise Miller Endowed Chair of Biomedical Engineering in 2007, and was Director of the NIH Nanomedicine Development Center relocated from Purdue to University of Cincinnati. He moved to University of Kentucky as William Farish Endowed Chair in Nanobiotechnology in 2012, and was the UK Director of Nanobiotechnology Center. In Jan 2016, he joined The Ohio State University College of Pharmacy as the first Sylvan G. Frank Endowed Chair in Pharmaceutics and Drug Delivery Systems. He is also currently the Director of NCI Cancer Nanotechnology Platform Partnership Program in RNA Nanotechnology for Cancer Therapy.

 He constructed the first viral DNA packaging motor in vitro (PNAS, 1986), discovered phi29 motor pRNA (Science, 1987), assembled infectious dsDNA viruses (J Virology, 1995), discovered pRNA hexamer (Mol Cell, 1998, featured in Cell), and pioneered RNA nanotechnology (Mol Cell, 1998, JNN, 2003; Nano Letter., 2004, 2005; Nature Nanotechnology 2010, 2011). His lab built a dual imaging system to detect single-fluorophores (EMBO J, 2007; RNA, 2007), incorporated the phi29 motor channel into a lipid membrane (Nature Nanotechnology, 2009) for single molecule sensing with potentials for high throughput dsDNA sequencing. Recently, his lab discovered a third class of biomotor using revolution mechanism without rotation. He is an editor or board member of five nanotech journals. He was a member of two prominent national nanotech initiatives sponsored by NIST, NIH, NSF and National Council of Nanotechnology; director of one NIH Nanomedicine Development Center from 2006 to 2011.